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UnknownSUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling.
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S-EPMC5581236 | biostudies-literature
ProteomicsDe Novo Sequencing of N-Glycosylated Light Chains in AL Amyloidosis
We established an integrative de novo sequencing workflow to resolve the complete amino acid sequence of N-glycosylated LCs isolated from the urine of AL patients.
ORGANISM(S): Homo Sapiens 
2026-04-16 | PXD077287 |
ProteomicsComprehensive N-Glycomics Profiling of Urinary Extracellular Vesicles Identifies a Novel Biomarker Panel for Diagnosis of Bladder Cancer
Bladder cancer (BC) is the most common urologic malignancy, facing enormous diagnostic challenges.Urinary extracellular vesicles (EVs) is a particularly promising source for developing diagnostic markers for bladder cancer because of the direct contact between urine and bladder. We investigate bioma...
ORGANISM(S): Homo Sapiens 
2024-11-14 | PXD057882 |
ProteomicsComparative evaluation of methods for isolating extracellular vesicles from ICC cell culture supernatants: Insights into proteomic and glycomic analysis
Extracellular vesicles (EVs) are specialized nanoscale vesicular structures that act as mediators of intercellular communication, playing crucial roles in the pathological processes of cancers. Aberrant glycosylation is a hallmark of cancer, the analysis of EVs and protein glycosylation provides val...
ORGANISM(S): Homo Sapiens 
2025-03-24 | PXD062160 |
ProteomicsProteomic Profiling in HeLa Cells
This study combined co-immunoprecipitation (Co-IP) and LC-MS/MS proteomics in MARCH8-overexpressing HeLa cells to identify potential substrates of the E3 ubiquitin ligase MARCH8. Using empty vector-transfected cells as controls, we generated a comprehensive protein interaction dataset to elucidate M...
ORGANISM(S): Homo Sapiens 
2025-03-23 | PXD062157 |
ProteomicsFecal protein changes in different colorectal diseases
We examined fecal proteins from normal subjects (n=6), patients with inflammatory bowel disease (n=8), patients with colorectal adenoma (n=8), and patients with colorectal cancer (n=14) in the hope of identifying novel fecal protein markers that could be used to identify colorectal diseases.
ORGANISM(S): Homo Sapiens 
2022-12-22 | PXD039089 |
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