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ProteomicsProteomics analysis of extracellular vesicles
Extracellular vesicles (EVs) isolated from HEK293-BRS-3 cells conditional media after activation and inhibition.
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD027980 | Pride
Bombesin receptor-subtype 3 Extracellular vesicles Proteomics 
ProteomicsActivation of dimerized BRS3-EP3 suppresses melanoma cell migration through coupling Gαs protein
The mechanism underlying the crosstalk between Gαq-coupled bombesin receptor subtype-3 (BRS3) and Gαi-coupled E-prostanoid 3 receptor (EP3) remains unknown. Here, we report that BRS3 and EP3 form dimers in the membrane of living HEK-293T cells. Interestingly, we found that BRS3-EP3 dimers switched t...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD042449 | Pride
Bombesin receptor subtype-3 E-prostanoid 3 receptor Cell migration Proteomics G-protein-coupled receptors dimerization 
ProteomicsZfp260 choreographs the early stage lineage commitment of skeletal stem cells
Zfp260 choreographs the early stage lineage commitment of skeletal stem cells
ORGANISM(S): Mus Musculus 
2024-11-14 | PXD057880 |
ProteomicsTestosterone delays bone loss and microstructural destruction in elderly men via osteoblast-androgen receptor-mediated upregulation of the fibrinogen C-terminus of tenascin-C
Bone loss in elderly males is associated with a high mortality rate because of fracture. A growing body of evidence indicates that low androgen levels are linked with bone loss in elderly men, suggesting that the regulatory role of androgen in aged male bones deserves more attention, and it is not e...
ORGANISM(S): Mus Musculus 
2024-05-14 | PXD052247 |
ProteomicsAnalysis of the structure of the MTA1 complex using chemical cross-linking mass spectrometry
Analysis of the structure of the MTA1 complex using chemical cross-linking mass spectrometry
ORGANISM(S): Tetrahymena Thermophila Sb210 
2022-11-30 | PXD038459 |
ProteomicsAI-empowered integrative structural characterization of m6A writer complex
Investigation into the structure of the human m6A writer complex.
ORGANISM(S): Homo Sapiens 
2022-08-18 | PXD036144 |
ProteomicsA CHKA–PML autophagy checkpoint enables tumors to evade glutamine starvation
CHKA phosphorylates PML at Tyr339 to promote its cytoplasmic localization; cytoplasmic PML then induces WIPI2 SUMOylation at Lys281/283, blocking HUWE1-mediated degradation. Stabilized WIPI2 enhances autophagic flux and supports tumor cell survival under metabolic stress.
ORGANISM(S): Homo Sapiens 
2026-03-03 | PXD075116 |
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