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TranscriptomicsDNA methylome signature in rheumatoid arthritis
Objectives: Epigenetics can influence disease susceptibility and severity. While DNA methylation of individual genes has been explored in autoimmunity, no unbiased systematic analyses have been reported. Therefore, a genome-wide evaluation of DNA methylation loci in fibroblast-like synoviocytes (FLS...
ORGANISM(S): Homo sapiens 
2013-04-25 | E-GEOD-46364 | biostudies-arrayexpress
MetabolomicsCASMDB: An Open-Source Database of Metabolite Annotation Data for 1D 1 H NMR-Based Metabolomics
In metabolomics analyses, databases are invaluable for the identification of individual metabolites in experimentally collected samples. Publicly available databases for NMR-based metabolomics are unfortunately incomplete with respect to experimental conditions, such as pH, temperature, and NMR fiel...
2026-04-21 | MTBLS6263 | MetaboLights
UnknownPhase II Investigator-Initiated Study of Brentuximab Vedotin in Mycosis Fungoides and Sezary Syndrome With Variable CD30 Expression Level: A Multi-Institution Collaborative Project.
Not available
S-EPMC5089160 | biostudies-literature
ProteomicsGlycomic and proteomic analyses of malignant ascites fluid were used to identify potential metastatic biomarkers of epithelial ovarian cancer : Partial
Ovarian cancer is a major cause of cancer mortality among women largely due to late diagnosis of advanced stage metastatic disease. More extensive molecular analysis of metastatic ovarian cancer is needed to identify post-translational modifications of proteins particularly associated with metastati...
ORGANISM(S): Homo sapiens (Human) 
2016-08-15 | PXD003794 | Pride
Ascites Concanavalin a Epithelial ovarian cancer 
UnknownThe Rheumatoid Arthritis Risk Gene LBH Regulates Growth in Fibroblast-like Synoviocytes.
Not available
S-EPMC4490933 | biostudies-literature
TranscriptomicsExpression data from H9 human embryonic stem cells (hESCs) differentiated to Early Mesoendoderm
We used microarrays to detail the global programme of gene expression during early hESC differentiation to Mesendoderm using FBS. Samples of hESCs were taken at undifferentiated state (0h), 8h of differentiation, 24h of differentiation, and 72h of differentiation with three replicates (A, B, and C) ...
ORGANISM(S): Homo sapiens 
2016-03-22 | E-GEOD-74004 | biostudies-arrayexpress
GenomicsHistone H3 Lysine4 Acetylation-Methylation Dynamics Define Breast Cancer Subtypes [ChIP-seq]
The molecular signature at histone H3K4 involved in epigenetic regulation of normal (MCF10A) and transformed (MCF7, MDA-MB-231) breast cells using ChIP-Seq technology. This study examines the dynamic distribution of H3K4me3 and H3K4ac histone modification associated with active chromatin to provide...
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-69377 | biostudies-arrayexpress
ProteomicsConserved hydrophilic checkpoints tune FocA-1 mediated formate:H+ symport
FocA belongs to the widespread, evolutionarily ancient formate-nitrite transporter 30 (FNT) family of pentameric anion channels and translocates formic acid bidirectionally. 31 Here, we identify compartmentalized polarity distribution across the complete FocA 32 pore structure – resolved at 2.56 Å –...
ORGANISM(S): Escherichia coli 
2025-11-10 | PXD054538 | Pride
Foca Xlms Cryo em Formate-nitrite transporter 
ProteomicsFight-or-flight responses require augmentation of Ca2+ influx via Rad phosphorylation
Fight-or-flight responses involve β-adrenergic-induced increases in heart rate and contractile force. Despite decades of investigations, predominantly focusing on ryanodine receptor and phospholamban phosphorylation, the molecular mechanisms underlying the sympathetic nervous system control of cardi...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-26 | PXD033492 | Pride
Contractility Heart Mass spectrometry Adrenergic Calcium Phosphorylation Pka Phosphatases Ion channels 
GenomicsInternational Consortium on the Genetics of Systemic Lupus Erythematosus (SLEGEN)

The genetic makeup of an individual strongly influences the risk of developing systemic lupus erythematosus (SLE). The identification of genes that predispose an individual to SLE will lead to earlier and better diagnosis, better treatments, and possibly prevention.

To this end, t...

phs000216.v1.p1 | EGA
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