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ProteomicsQuantitative chemical proteomic profiling of phosphoprotein phosphatases
We have developed a chemical proteomic strategy for the systematic interrogation of endogenous phosphoprotein phosphatases (PPP) and their interacting proteins, including regulatory and scaffolding subunits, and substrates (the 'PPPome'). PPPs are captured using an immobilized non-selective PPP inhi...
ORGANISM(S): Neurospora Crassa (ncbitaxon:5141) Candida Albicans (ncbitaxon:5476) Saccharomyces Cerevisiae (ncbitaxon:4932) Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) Schizosaccharomyces Pombe (ncbitaxon:4896) 
2017-07-07 | MSV000081226 | MassIVE
GenomicsArabidopsis PP6 phosphatases dephosphorylate PIF proteins to repress photomorphogenesis.
Arabidopsis PP6 phosphatases dephosphorylate PIF proteins to repress photomorphogenesis.
PRJNA527851 | ENA
ProteomicsPeptide probes containing a non-hydrolyzable phosphotyrosine-mimetic residue as a tool for tyrosine phosphatomics
Protein tyrosine phosphatases (PTPs) cooperate with protein tyrosine kinases to regulate intracellular tyrosine phosphorylation levels, and their dysfunction is associated with various diseases. However, due to the low abundance of PTPs in cells, comprehensive analysis requires an enrichment step pr...
ORGANISM(S): Homo Sapiens (human) 
2021-10-27 | PXD025038 | JPOST Repository
ProteomicsIdentification of phosphatases that dephosphorylate Tom6 using synthetic trap-peptides
The identification of phosphatases that dephosphorylate specific sites in proteins remains a major challenge, particularly for the major class of serine/threonine-specific phosphatases, which function as holoenzymes. Here, we report the development of synthetic trap-peptides to identify phosphatases...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-06-16 | PXD058384 | Pride
Trap-peptides Phosphatases Pfa Psy2 Pp2a Cdc55 Tom complex Protein import Pp4 Tom6 
ProteomicsSerine/threonine phosphatases and aquaporin-2 regulation in renal collecting duct
Phosphorylation of the aquaporin-2 (AQP2) water channel at four COOH-terminal serines plays a central role in the regulation of water permeability of the renal collecting duct. The level of phosphorylation at these sites is determined by a balance between phosphorylation by protein kinases and depho...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-10-26 | PXD005488 | Pride
Systems biology  collecting duct  kidney  vasopressin  lc-ms/ms 
GenomicsTranscriptional regulon controlled by tyrosine phosphatases in Porphyromonas gingivalis
Transcriptional regulon controlled by tyrosine phosphatases in Porphyromonas gingivalis
PRJNA1272481 | ENA
GenomicsThe role of protein phosphatases in cellulase regulation in Trichoderma reesei
The role of protein phosphatases in cellulase regulation in Trichoderma reesei
PRJNA998449 | ENA
TranscriptomicsTranscription profiling of uteri from gonadectomized C57BL/6 mice injected with 17-Estradiol (E2) to identify genes modulated by a physiological dose of E2 in uterus.
17ß-Estradiol (E2) is well known to be associated with uterine cancer, endometriosis, and leiomyomas. Although insulin-like growth factor I (IGF-I) has been identified as a mediator of the uterotrophic effect of E2 in several studies, this mechanism is still not well understood. In the present stud...
ORGANISM(S): Mus musculus 
2007-11-14 | E-GEOD-6219 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lung fibroblasts (HLF) treated with Cr(VI) a carcingogen in the presence of PTP to investigate the effect of protein tyrosine phosphatases inhibition on changes in gene expression
Although the consequences of genotoxic injury include cell cycle arrest and apoptosis, cell survival responses after genotoxic injury can produce intrinsic death-resistance and contribute to the development of a transformed phenotype. Protein tyrosine phosphatases (PTPs) are integral components of k...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-12205 | biostudies-arrayexpress
TranscriptomicsArabidopsis PP6 phosphatases dephosphorylate PIF proteins to repress photomorphogenesis.
Light-induced phosphorylation is necessary and essential for the degradation of phytochrome-interacting factors (PIFs), the central repressors of photomorphogenesis. Although the kinases responsible for PIF phosphorylation have been extensively studied, the phosphatases underlying PIF dephosphorylat...
ORGANISM(S): Arabidopsis thaliana 
2019-09-04 | GSE128498 | GEO
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