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ProteomicsSIRT1 regulates DNA damage signaling through PP4 phosphatase complex
The Sirtuin family of NAD+-dependent enzymes play an important role in the maintenance of genome stability upon stress. Several mammalian Sirtuins have been linked directly or indirectly to the regulation of DNA damage during replication through Homologous recombination (HR). The role of one of them...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-06-15 | PXD036905 | Pride
Label free proteomics Pp4 phosphatase complex H2ax Sirt1 Dna damage response 
ProteomicsPervasive phenotypic effects of FBXO42 promoted by regulation of PP4 phosphatase
F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin–F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of key cellular processes, including cell cycle progression, DNA damage response and glioma stem cell su...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD069542 | Pride
Cancer Fbxo42 Scf Ppp phosphatases Ubiquitin 
ProteomicsPervasive phenotypic effects of FBXO42 promoted by regulation of PP4 phosphatase
Abstract F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin–F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of key cellular processes, including cell cycle progression, DNA damage response and glioma ste...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD069593 | Pride
Cancer Fbxo42 Scf Ppp phosphatases Ubiquitin 
ProteomicsPervasive phenotypic effects of FBXO42 promoted by regulation of PP4 phosphatase
F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin–F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of key cellular processes, including cell cycle progression, DNA damage response and glioma stem cell su...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD069496 | Pride
Cancer Fbxo42 Scf Ppp phosphatases Ubiquitin 
UnknownA Consensus Binding Motif for the PP4 Protein Phosphatase.
Not available
S-EPMC6981294 | biostudies-literature
ProteomicsA consensus binding motif for the PP4 protein phosphatase reveals its role as a regulator of cohesin release
Regulation of protein activities through phosphorylation is a fundamental regulatory mechanism in all organisms. Phosphoprotein phosphatase 4 (PP4) is a conserved and essential enzyme that dephosphorylates serine and threonine residues in substrates. Despite the importance of PP4 general principles ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-02-13 | MSV000083438 | MassIVE
UnknownPP4 is essential for germinal center formation and class switch recombination in mice.
Not available
S-EPMC4162579 | biostudies-literature
UnknownPP4 dephosphorylates Maf1 to couple multiple stress conditions to RNA polymerase III repression.
Not available
S-EPMC3321174 | biostudies-literature
UnknownNovel perspectives of target-binding by the evolutionarily conserved PP4 phosphatase.
Not available
S-EPMC7776573 | biostudies-literature
UnknownPervasive phenotypic effects of FBXO42 are promoted by regulation of PP4 phosphatase.
Not available
S-EPMC12909836 | biostudies-literature
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