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GenomicsEpigenetics profiling of human BLaER1 pre-B cells transdifferentiation into macrophages
BLaER1 is a human B cell precursor leukemia cell line derived from the RCH-ACV cells. These cells are stably infected with a construct that overexpresses the transcription factor C/EBPa fused with the estrogen receptor hormone binding domain (ER) and GFP. Upon induction with beta-estradiol, C/EBP is...
ORGANISM(S): Homo sapiens 
2022-05-31 | E-MTAB-9825 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat liver samples from animals treated with D-penicillamine and controls
Idiosyncratic drug reactions (IDRs) cause significant morbidity and mortality. In an animal model of IDRs, 50-80% of Brown Norway rats exposed to D-penicillamine develop an autoimmune syndrome after several weeks of treatment. The symptoms of the IDR are similar to that observed in humans who take D...
ORGANISM(S): Rattus norvegicus 
2007-10-10 | E-GEOD-2825 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human T cell lines isolated from tumor infiltrating lymphocytes or peripheral blood lymphocytes of a patient with large cell carcinoma of the lung
The IGR-Heu tumor cell line was established from patient Heu suffering from large cell carcinoma of the lung. Heu171, Heu127 and Heu161 T cell clones were isolated from autologous tumor infiltrating lymphocytes. H32 T cell line and H32-22 clone were isolated from autologous PBL after stimulation wit...
ORGANISM(S): Homo sapiens 
2007-03-02 | E-TABM-208 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Listeria monocytogenes wild type and prfA, sigB and hfq deletion mutants grown in different media and at different temperatures
Comparison of Listeria monocyotgenes gene expression in different growth conditions (exponential phase 37 degrees C, stationary phase 37 degrees C, exponential phase 30 degrees C, hypoxia, human blood, murine intestinal lumen) and different mutant strains (wild-type versus prfA, sigB and hfq deletio...
ORGANISM(S): Listeria monocytogenes 
2010-04-16 | E-MEXP-2138 | biostudies-arrayexpress
TranscriptomicsTiling path analysis of Listeria monocytogenes wild type and prfA, sigB and hfq deletion mutants grown in different media and at different temperatures
Comparison of Listeria monocytogenes transcripts in different growth conditions (exponential phase 37 degrees C, stationary phase 37 degrees C, exponential phase 30 degrees C, hypoxia, human blood, murine intestinal lumen) and different mutant strains (wild-type versus prfA, sigB and hfq deletion mu...
ORGANISM(S): Listeria monocytogenes 
2009-04-24 | E-MEXP-2142 | biostudies-arrayexpress
GenomicsDynamics of SREBP1 binding to DNA in mouse liver
To systematically understand how the circadian clock and the nutrient-driven rhythm integrate to regulate SREBP1 activity, we evaluated genome-wide the binding of SREBP1 to its targets along the day in wild-type (WT) C57BL/6mice. The recruitment of SREBP1 to the DNA showed a highly circadian behavio...
ORGANISM(S): Mus musculus 
2014-03-10 | E-GEOD-48375 | biostudies-arrayexpress
GenomicsLong-range bidirectional transcription is a general feature of developmental gene promoters in mammals (ChIP-Seq 1)
Recent studies have revealed a myriad of non-coding transcripts in different organisms. For instances, the presence of short bidirectional transcripts is a hallmark of active promoters in mammals, while upstream non-coding transcripts can be detected at most expressed genes in conditions where the R...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-44577 | biostudies-arrayexpress
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