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TranscriptomicsIdentification of sigB inhibitors in L. monocytogenes
The extensively studied intracellular pathogen, L. monocytogenes, is an ideal model for identifying small-molecule agents for treating bacterial infections. By selecting specific biological targets in L. monocytogenes, which are common to Gram-positive pathogens, we could extrapolate drug discovery ...
ORGANISM(S): Listeria monocytogenes 10403S 
2011-12-06 | E-GEOD-16887 | biostudies-arrayexpress
MetabolomicsSeasonal and day/night variations of microbial metabolic functioning in simulated cloud water

Microorganisms maintain metabolic activity in clouds, with recognized impacts on chemical reactivity by contributing to the processing of small organic compounds, radicals and their precursors. However, the conditions in clouds can be highly contrasted (temperature, light, etc), and it remains un...

2026-02-12 | MTBLS12281 | MetaboLights
TranscriptomicsSigma factor B (sigB) response to stress conditions (0.05% SDS and 5mM Diamide)
The numerous sigma factors present in Mycobacterium tuberculosis (MTB) are indicative of adaptability to different environmental conditions. In this report we describe the sigma factor B (sigB) regulon and the phenotypes of a MTB sigB mutant strain exposed to different stresses like SDS and Diamide....
ORGANISM(S): Mycobacterium tuberculosis 
2010-06-25 | E-GEOD-15976 | biostudies-arrayexpress
TranscriptomicsThe response of Mycobacterium tuberculosis to reactive oxygen and nitrogen species
The bacteriostatic and bactericidal effects and the corresponding expression profiles of Mycobacterium tuberculosis to representative oxidative and nitrosative stresses were investigated by growth and survival studies and whole genome expression analysis. The response of M. tuberculosis to a range ...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-18 | E-GEOD-16146 | biostudies-arrayexpress
MetabolomicsTranscript, protein and metabolite temporal dynamics in the CAM plant Agave
Already a proven mechanism for drought sustainability, crassulacean acid metabolism (CAM) is a specialized type of photosynthesis that maximizes water-use efficiency (WUE) via an inverse (compared to C3 and C4 photosynthesis-performing species) day/night pattern of stomatal closure/opening to shift ...
2017-10-13 | MTBLS363 | MetaboLights
TranscriptomicsThe effect of growth rate on pyrazinamide activity in Mycobacterium tuberculosis; insights for early bactericidal activity
Background: Pyrazinamide (PZA) plays an essential part in the shortened 6-month tuberculosis (TB) treatment course due to its activity against slow-growing, semi-dormant organisms. We tested the paradigm that PZA preferentially targets slow growing cells of Mycobacterium tuberculosis that remain aft...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2016-03-25 | E-MTAB-4093 | biostudies-arrayexpress
TranscriptomicsGeoChip 5 microarray data to determine gene activity in microbially influenced corrosion and associated samples from Shoreham Harbour, U.K.
Samples collect to investigate the gene activity from microbial populations in marine steel corrosion, and to compare with gene activity in water and bed sediment samples from the surrounding area. The study was undertaken to (1) investigate mechanisms of microbially influenced corrosion (MIC) of ma...
ORGANISM(S): mixed sample 
2019-11-01 | E-MTAB-8364 | biostudies-arrayexpress
TranscriptomicsCbf11 Regulates Periodic Expression of Genes Required to Prevent Catastrophic Mitosis in the Fission Yeast Cell Cycle
The expression of a large proportion of the fission yeast genome changes periodically with the cell cycle. Several key transcription factors have been identified that regulate these oscillating and interdependent waves of gene expression. However, for a significant number of cell cycle-regulated gen...
ORGANISM(S): Schizosaccharomyces pombe 
2015-09-18 | E-MTAB-2724 | biostudies-arrayexpress
TranscriptomicsInhibition of Respiration by Nitric Oxide Induces a Mycobacterium tuberculosis Dormancy Program
An estimated two billion persons are latently infected with Mycobacterium tuberculosis. The host factors that initiate and maintain this latent state and the mechanisms by which M. tuberculosis survives within latent lesions are compelling but unanswered questions. One such host factor may be nitric...
ORGANISM(S): Mycobacterium tuberculosis 
2007-08-21 | E-GEOD-8839 | biostudies-arrayexpress
TranscriptomicsThe small RNA diversity from Medicago truncatula roots under biotic interactions evidences the environmental plasticity of the miRNAome
Plants show a remarkable plasticity to adapt their root architecture to biotic and abiotic constraints of the soil environment. Although some of these modifications are fine-tuned by miRNAs, there are still shadow zones in these regulations. In the model legume Medicago truncatula, we analyzed the ...
ORGANISM(S): Medicago truncatula 
2014-08-15 | E-GEOD-49226 | biostudies-arrayexpress
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