Sort   by:  
 Page size 
MetabolomicsExploring the Impact of Sleep Deprivation on the Characteristics and Associations of Oral-Gut Microbiota in Adolescents with Comorbidity of Dental Caries and Obesity
We conducted a cross-sectional study involving 85 adolescents aged 12–15 years, divided into healthy controls (HC), caries-obesity comorbidity (CO), and caries-obesity with sleep deprivation (COS) groups. Oral and fecal samples were collected for 16S rRNA gene sequencing, untargeted metabolomics, an...
2026-04-29 | MTBLS14395 | MetaboLights
MetabolomicsToxoplasma gondii metabolic flexibility in response to iron deprivation

Iron is an essential nutrient for many critical cellular processes. As a consequence of diverse and dynamic host environments, the obligate intracellular parasite Toxoplasma gondii must adapt to iron limited conditions. To investigate the adaptations critical to parasite survival under these cond...

2026-03-18 | MTBLS12831 | MetaboLights
MetabolomicsAromatic amino acids metabolism shapes autophagy mediated adaptation to iron deprivation in glioma

GBM displays profound iron dependence and metabolic plasticity, yet how iron deprivation interfaces with stress-response pathways and amino acid metabolism in glioma remains incompletely understood. DFO, an iron chelator and hypoxia mimetic, is widely used experimentally, but the integration of a...

2026-08-20 | MTBLS15394 | MetaboLights
TranscriptomicsExpression data from sleep deprivation experiment in mouse hippocampus
We used microarrays to detail the global programme of gene expression underlying the effect of sleep deprivation in the mouse hippocampus and identified distinct classes of regulated genes during this process. Hippocampal tissue was taken from sleep deprived mice and time-matched non-sleep-deprived ...
ORGANISM(S): Mus musculus 
2012-09-06 | E-GEOD-33302 | biostudies-arrayexpress
MetabolomicsFood Deprivation Enhances Disease Resistance: Underlying Mechanisms in Oysters Confronted with Pacific Oyster Mortality Syndrome

Variation in food availability can shape host susceptibility and pathogen virulence, thereby impacting disease outcomes. An ad libitum diet may enhance host physiology and immunity but it can also favor pathogen proliferation. Here, we investigated how food availability (ad libitum vs. starvation...

2025-11-14 | MTBLS13313 | MetaboLights
TranscriptomicsThe Influence of Sleep Deprivation on Hippocampal CA1 Gene Expression: Relation to Stress and Aging
Sleep deprivation (SD) in young adults is associated with metabolic, stress and cognitive responses that are also characteristic of brain aging. Given that sleep architecture changes with age, including increased fragmentation and decreased slow wave activity, it seems reasonable to investigate pote...
ORGANISM(S): Rattus norvegicus 
2012-07-16 | E-GEOD-34424 | biostudies-arrayexpress
TranscriptomicsTranscriptome of Legionella pneumophila rpoS mutant in water
Legionella pneumophila is a water-borne pathogen, and thus survival in the aquatic environment is central to its transmission to humans. Hence, identifying genes required for its survival in water could help prevent Legionnaires’ disease outbreaks. In the present study, we investigate for the first ...
ORGANISM(S): Legionella pneumophila subsp. pneumophila str. Philadelphia 1 
2014-12-04 | E-GEOD-56258 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression analysis of maize leaf at heading stage in response to water-deficit stress
Periods of soil water deficit could occur at any time during the crop season, but maize is particularly sensitive to water stress around flowering time. At this time the stress usually causes remarkable yield loss. Heading time, which is just before tassel flowering, is one of the most important sta...
ORGANISM(S): Zea mays 
2010-05-26 | E-GEOD-10596 | biostudies-arrayexpress
MetabolomicsThe response of Chlamydomonas reinhardtii to nitrogen deprivation: a systems biology analysis

Drastic alteration in macronutrients causes large changes in gene expression in the photosynthetic unicellular alga Chlamydomonas reinhardtii. Preliminary data suggested that cells follow a biphasic response to this change hinging on the initiation of lipid accumulation, and we hypothesized that ...

2015-06-29 | MTBLS208 | MetaboLights
TranscriptomicsTranscription profiling of mouse brain during spontaneous sleep and prolonged wakefulness
These studies address temporal changes in gene expression during spontaneous sleep and extended wakefulness in the mouse cerebral cortex, a neuronal target for processes that control sleep; and the hypothalamus, an important site of sleep regulatory processes. We determined these changes by comparin...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6514 | biostudies-arrayexpress
Sort   by:  
 Page size