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ProteomicsHypoxia induces hypersecretory phenotype, impaired ciliary function and altered CFTR activity in air-liquid interface cultures of cystic fibrosis primary nasal epithelial cells. (Stem cell)
Atmospheric oxygen tension is increasingly recognized to be hyperoxic for the maintenance of in vitro cell cultures. Oxygen has broad implications on energy metabolism, cellular growth and many regulatory functions. Primary airway epithelial cells (AECs) differentiated at air-liquid interface (ALI) ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-25 | PXD038852 | Pride
Hypoxia Cystic fibrosis 
ProteomicsHypoxia induces hypersecretory phenotype, impaired ciliary function and altered CFTR activity in air-liquid interface cultures of cystic fibrosis primary nasal epithelial cells. (ALI cell)
Atmospheric oxygen tension is increasingly recognized to be hyperoxic for the maintenance of in vitro cell cultures. Oxygen has broad implications on energy metabolism, cellular growth and many regulatory functions. Primary airway epithelial cells (AECs) differentiated at air-liquid interface (ALI) ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-25 | PXD038893 | Pride
Hypoxia Cystic fibrosis 
ProteomicsTryptophan zipper hydrogels: bioactive self-healing antimicrobial matrices
Natural materials can reversibly self-assemble into hierarchical networks with diverse structural and functional properties. Recreating these dynamic architectures using peptide-based synthetic materials has been an elusive goal, hindered by challenges in relating sequence to structure to function. ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-25 | PXD038870 | Pride
Organoids Matrigel Hydrogel 
ProteomicsConditionally reprogrammed (CRC) and feeder free SMAD inhibited (SMADi) expanded human nasal epithelial cells label-free LC-MS/MS
Discovery of therapies that are able to correct defective CFTR requires patient derived in vitro pre-clinical cell models to be developed. Two main approaches exist to expand bronchial and nasal cultures, such as conditionally reprogrammed cells (CRC) and feeder free dual SMAD inhibition (SMADi) to ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-05 | PXD018386 | Pride
Human nasal epithelial cells Cystic fibrosis Conditionally reprogrammed cells Label-free lc-ms/ms Smad inhibition 
Proteomicsγ-glutamylcysteine (GGC) supplementation and p-LPS challenge causes distinct proteomic changes to primary airway epithelial cell models of Cystic Fibrosis
Cystic fibrosis (CF) is a life limiting inherited condition associated with recurrent bacterial infections, inflammation, oxidative stress and loss of lung function. CF is characterised by deficiencies in both intra- and extracellular glutathione (GSH) levels. This GSH depletion is exacerbated by ba...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019084 | Pride
Lps Glutathione Cystic fibrosis Airway epithelial cells Qlc-ms/ms Γ-glutamylcysteine Oxidative stress 
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