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ProteomicsThe anti-MRSA compound KCR inhibits protein synthesis in Staphylococcus aureus
S aureus was treated in triplicate with 3-O-alpha-L-(2",3"-di-p-coumaroyl)rhamnoside (KCR), oxacillin or vehicle and quantitative proteomic analysis was carried out using isobaric tags and mass spectrometry. 1190 proteins were identified and 552 were affected by KCR (q<0.01). Ontology analysis ide...
ORGANISM(S): Staphylococcus Aureus (ncbitaxon:1280) 
MSV000084282 | MassIVE
TranscriptomicsProtein kinase B-mediated phosphorylation controls binding of global transcriptional regulator Lsr2 to DNA in Mycobacterium tuberculosis
Two billion people are estimated to have latent tuberculosis infection associated with dormant Mycobacterium tuberculosis. Mycobacteria possess a great portfolio of regulatory proteins which that control transitions betweento dormancy and resuscitation, including the essential protein kinase B (PknB...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2019-10-02 | E-MTAB-7627 | biostudies-arrayexpress
MetabolomicsUntargeted metabolomics analyses and contaminant chemistry of Dreissenid mussels at the Maumee River Area of Concern in the Great Lakes

Bivalves serve as an ideal ecological indicator; hence, their use by the NOAA Mussel Watch Program to monitor environmental health. This study aimed to expand the baseline knowledge of using metabolic end points in environmental monitoring by investigating the dreissenid mussel metabolome in the ...

2024-06-03 | MTBLS6311 | MetaboLights
UnknownExtracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells.
Not available
S-EPMC6419691 | biostudies-literature
ProteomicsThe histone modification regulator, SIN3, plays a role in the cellular response to changes in glycolytic flux
Epigenetic regulation and metabolism are connected. Epigenetic regulators, like the SIN3 complex, affect the expression of a wide range of genes, including those encoding metabolic enzymes essential for central carbon metabolism. The idea that epigenetic modifiers can sense and respond to metabolic ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-10-14 | PXD058616 | Pride
Histone modification Respiration Gene regulation Energy metabolism Drosophila 
UnknownCarfilzomib in multiple myeloma patients with renal impairment: pharmacokinetics and safety.
Not available
S-EPMC3740399 | biostudies-literature
UnknownProcess of Withdrawal of Mechanical Ventilation at End of Life in the ICU: Clinician Perceptions.
Not available
S-EPMC11218830 | biostudies-literature
TranscriptomicsTranscription profiling of S. pneumonia early response to to THP-1 human macrophages
Transcriptional responses of an unencapsulated Streptococcus pneumoniae strain derived from TIGR4 to human macrophages THP-1 were investigated at the early stages of interactions (0.5 h, 1 h and 3h).
ORGANISM(S): Streptococcus pneumoniae 
2008-10-21 | E-FPMI-16 | biostudies-arrayexpress
UnknownHigh-dose AraC is essential for the treatment of ML-DS independent of postinduction MRD: results of the COG AAML1531 trial.
Not available
S-EPMC8662073 | biostudies-literature
UnknownTreatment with the Topical Antimicrobial Peptide Omiganan in Mild-to-Moderate Facial Seborrheic Dermatitis versus Ketoconazole and Placebo: Results of a Randomized Controlled Proof-of-Concept Trial.
Not available
S-EPMC10531869 | biostudies-literature
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