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ProteomicsWblC- and tetracycline-dependent shifts in the composition of Streptomyces coelicolor ribosomal proteome
WblC, also known as WhiB7, is a widely conserved WhiB-like transcription factor in actinomycetes that activates transcription of many targets upon antibiotic challenge to bring about intrinsic resistance to a wide range of translation-targeting antibiotics. As we found that WblC controls many genes ...
ORGANISM(S): Streptomyces coelicolor A3(2) 
2020-05-27 | PXD015538 | Pride
Streptomyces coelicolor Ribosome Whib7 Wblc Antibiotic stress 
GenomicsTranscriptome profiles of Streptomyces coelicolor A3(2) wild type and wblC (whiB7) mutant treated with tetracycline
Transcriptome profiles of Streptomyces coelicolor A3(2) wild type and wblC (whiB7) mutant treated with tetracycline
PRJNA561423 | ENA
GenomicsGenome-wide identification of WblC (WhiB7) binding sites in Streptomyces coelicolor A3(2) treated with tetracycline
Genome-wide identification of WblC (WhiB7) binding sites in Streptomyces coelicolor A3(2) treated with tetracycline
PRJNA561422 | ENA
TranscriptomicsTranscriptome profiles of Streptomyces coelicolor A3(2) wild type and wblC (whiB7) mutant treated with tetracycline
We determined Streptomyces coelicolor genes that are directly regulated by WblC (or WhiB7), an actinobacterial transcription factor that activates expression of intrinsic resistance in response to translation-inhibitory antibiotic stress. Identification of differentially expressed genes in wblC muta...
ORGANISM(S): Streptomyces coelicolor 
2020-03-28 | GSE136167 | GEO
GenomicsGenome-wide identification of WblC (WhiB7) binding sites in Streptomyces coelicolor A3(2) treated with tetracycline
We determined Streptomyces coelicolor genes that are directly regulated by WblC (or WhiB7), an actinobacterial transcription factor that activates expression of intrinsic resistance in response to translation-inhibitory antibiotic stress. Identification of differentially expressed genes in wblC muta...
ORGANISM(S): Streptomyces coelicolor 
2020-03-28 | GSE136166 | GEO
UnknownThe WblC/WhiB7 Transcription Factor Controls Intrinsic Resistance to Translation-Targeting Antibiotics by Altering Ribosome Composition.
Not available
S-EPMC7157823 | biostudies-literature
GenomicsGenome-wide identification of WblC (WhiB7) binding sites and Transcriptome profiles of Streptomyces coelicolor A3(2) wild type and wblC (whiB7) mutant treated with tetracycline
Genome-wide identification of WblC (WhiB7) binding sites and Transcriptome profiles of Streptomyces coelicolor A3(2) wild type and wblC (whiB7) mutant treated with tetracycline
PRJNA561418 | ENA
ProteomicsABCF Protein-Mediated Resistance Shapes Bacterial Responses Based on Antibiotic Type and Concentration
Antibiotic resistance (ARE) ABCF proteins are widespread, genome-encoded resistance factors in Gram-positive bacteria that rescue ribosomes stalled by antibiotics. In this study, we integrate genetic, proteomic, metabolomic, and biochemical approaches to reveal that ARE5 subfamily proteins, TiaA and...
ORGANISM(S): Streptomyces coelicolor 
2025-07-28 | PXD063714 | Pride
Streptomyces coelicolor Are acbf proteins Antibiotic resistance 
ProteomicsABCF Protein-Mediated Resistance Shapes Bacterial Responses Based on Antibiotic Type and Concentration
Antibiotic resistance (ARE) ABCF proteins are widespread, genome-encoded resistance factors in Gram-positive bacteria that rescue ribosomes stalled by antibiotics. In this study, we integrate genetic, proteomic, metabolomic, and biochemical approaches to reveal that ARE5 subfamily proteins, TiaA and...
ORGANISM(S): Streptomyces coelicolor 
2025-07-28 | PXD059630 | Pride
Are5 subfamily proteins Streptomyces coelicolor Antibiotic resistance Gram-positive bacteria 
UnknownInduction of a stable sigma factor SigR by translation-inhibiting antibiotics confers resistance to antibiotics.
Not available
S-EPMC4921905 | biostudies-literature
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