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UnknownBRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study Group.
Not available
S-EPMC3413277 | biostudies-literature
ProteomicsCG14435 (detour), the Drosophila ZNRF1 and 2 homologue, regulates autophagosome biogenesis critical for healthy aging
Autophagy is essential for animal development and homeostasis, and its deregulation is associated with numerous human pathologies. Here we identify a novel regulator of autophagy, the RING domain containing ubiquitin ligase CG14435 (detour). Depletion of CG14435 resulted in increased early-stage aut...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2024-05-21 | PXD036857 | Pride
Autophagy Drosophila Aging 
MetabolomicsMetabolic analysis of the response of Pseudomonas putida DOT-T1E strains to toluene using Fourier transform infrared spectroscopy and gas chromatography mass spectrometry
To elucidate any observable metabolic alterations during interactions of several strains of Pseudomonas putida (DOT-T1E, and its mutants DOT-T1E-PS28 and DOT-T1E-18) with the aromatic hydrocarbon toluene, metabolomic approaches were employed. Initially, Fourier-transform infrared (FT-IR) spectroscop...
2016-08-23 | MTBLS319 | MetaboLights
UnknownAssociation of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study.
Not available
S-EPMC5100621 | biostudies-literature
UnknownPhase III, randomized, double-blind, multicenter trial comparing orteronel (TAK-700) plus prednisone with placebo plus prednisone in patients with metastatic castration-resistant prostate cancer that has progressed during or after docetaxel-based therapy: ELM-PC 5.
Not available
S-EPMC4879718 | biostudies-literature
TranscriptomicsSox2 promotes malignancy in glioblastoma by regulating plasticity and astrocytic differentiation
Making use of a previously described isogenic cancer stem cells and serum differentiated cultures we show that Sox2 controls developmental stated specific programs in glioblastoma. Glioblastoma cells were cultured as control and with SOX2 knockdown to identify the scope of SOX2 interactions. The SOX...
ORGANISM(S): Homo sapiens 
2014-07-22 | E-GEOD-51441 | biostudies-arrayexpress
UnknownModelling changes in glutathione homeostasis as a function of quinone redox metabolism.
Not available
S-EPMC6474874 | biostudies-literature
TranscriptomicsMolecular-guided therapy predictions reveal drug resistance phenotypes and treatment alternatives in malignant peripheral nerve sheath tumors
Use existing public data, cell lines and patient tumors with a personalized medicine approach to predict effective therapies for treatment of Neurofibroma tumors. Compare expression profile to reference set to identify over expressed genes that are drugable targets.
ORGANISM(S): Homo sapiens 
2014-07-22 | E-GEOD-50208 | biostudies-arrayexpress
GenomicsComprehensive analysis of orphan CpG islands identifes novel promoters with conserved DNA methylation dynamics
We report the application of single molecule-based sequencing technology in combination with CXXC affinity purifcation (CAP-seq), MBD affinity purification (MAP-seq) and chromatin immunoprecipitation (ChIP-seq) to generate reciprocal methylation and chromatin modifcation maps in human and mouse. We ...
ORGANISM(S): Mus musculus 
2010-10-04 | E-GEOD-21442 | biostudies-arrayexpress
TranscriptomicsProspective molecular profiling of canine cancers provides a clinically relevant comparative model for evaluating precision medicine (PMed) trials
Feasibility trial to examine the ability to conduct molecular guided therapy in a geographically distributed systems within strict time constraints Canine patients were enrolled across a broad panel of tumor types where tumor samples were acquired and processed to preserve RNA quality for genomic an...
ORGANISM(S): Canis lupus 
2014-04-28 | E-GEOD-51131 | biostudies-arrayexpress
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