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GenomicsNucleosomes are context-specific, H2A.Z modulated barriers to RNA polymerase
Nucleosomes are barriers to transcription in vitro, however, their effects on RNA polymerase in vivo are unknown. Here we describe a simple and general strategy to comprehensively map the positions of elongating and arrested RNA Polymerase II (RNAPII) at nucleotide resolution. Our results suggest th...
ORGANISM(S): Drosophila melanogaster 
2014-03-06 | E-GEOD-49106 | biostudies-arrayexpress
UnknownCase Report: Ocular Microsporidiosis: Case in a Patient Returning from India and Review of the Literature.
Not available
S-EPMC6085796 | biostudies-literature
UnknownOverall Survival in Patients With Advanced Melanoma Who Received Nivolumab Versus Investigator's Choice Chemotherapy in CheckMate 037: A Randomized, Controlled, Open-Label Phase III Trial.
Not available
S-EPMC6804912 | biostudies-literature
UnknownEfficacy and Safety of Nivolumab Alone or in Combination With Ipilimumab in Patients With Mucosal Melanoma: A Pooled Analysis.
Not available
S-EPMC5559888 | biostudies-literature
TranscriptomicsRNA-seq of mouse sorted alveolar macrophages
Sequencing of sorted alveolar macrophages (AMs) from WT mice, or from SPAM deleter (SPecific AM deleter; Siglecf-fl-DTR-fl x Epx-Cre) mice with adoptively transferred donor AMs, treated with PBS or 3 x interleukin-33 (IL33). Experiment 1 compares AMs from PBS treated and IL-33 treated WT mice and AM...
ORGANISM(S): Mus musculus 
2025-12-12 | E-MTAB-15952 | biostudies-arrayexpress
TranscriptomicsGenome-wide methylation profiling identifies hypermethylated biomarkers in high-grade cervical intraepithelial neoplasia
Epigenetic modifications, such as aberrant DNA promoter methylation is frequently observed in cervical cancer. Identification of hypermethylated regions maybe useful for discrimination between normal cervical epithelium and high-grade cervical intraepithelial neoplasia (CIN2/3) or worse may improve ...
ORGANISM(S): Homo sapiens 
2012-11-01 | E-GEOD-36319 | biostudies-arrayexpress
UnknownOptimal priming of poxvirus vector (NYVAC)-based HIV vaccine regimens for T cell responses requires three DNA injections. Results of the randomized multicentre EV03/ANRS VAC20 Phase I/II Trial.
Not available
S-EPMC7319597 | biostudies-literature
TranscriptomicsMyocardial gene expression of type 2 diabetic mice with and without treatment with glucokinase activator
Chronic inflammation is a hallmark of obesity type II diabetes (T2D) accompanied by increased circulating inflammatory T-cells. Diabetic cardiomyopathy (dbCM) is characterised by systemic inflammation, disrupted metabolism and impaired cardiac function. However, whether T-cell mediated cardiac autoi...
ORGANISM(S): Mus musculus 
2025-12-04 | E-MTAB-13849 | biostudies-arrayexpress
TranscriptomicsMyeloid cell expression of COMMD1 is required to restrain pro-inflammatory gene expression and tissue inflammation
Inflammation is a hallmark of multiple disease processes, including inflammatory bowel disease (IBD). The transcription factor NF-kappaB plays a critical role in this response through its effects on pro-inflammatory gene expression. Consequently, homeostatic mechanisms that control NF-kappaB activit...
ORGANISM(S): Mus musculus 
2014-05-19 | E-GEOD-53368 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome analysis reveals genes associated with variation in liver copper concentration in Polish-Merino sheep
The aim of this study is to assess the transcriptome for genes that are differentially expresed in liver tissues with high or low liver copper concentration in sheep. Therefore, 12 liver samples high and low liver copper were selected and grouped equally into high liver copper and low liver copper g...
ORGANISM(S): Ovis aries 
2025-03-02 | E-MTAB-14752 | biostudies-arrayexpress
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