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TranscriptomicsB-cell tumor development in Tet2-deficient mice
The TET2 gene encodes an α-ketoglutarate-dependent dioxygenase able to oxidize 5-methylcytosine into 5-hydroxymethylcytosine, which is a step toward active DNA demethylation. TET2 is frequently mutated in myeloid malignancies but also in B- and T-cell malignancies. TET2 somatic mutations are also id...
ORGANISM(S): Mus musculus 
2019-12-12 | E-MTAB-8501 | biostudies-arrayexpress
UnknownIntrathecal anti-CD20 efficiently depletes meningeal B cells in CNS autoimmunity.
Not available
S-EPMC4184778 | biostudies-literature
UnknownB cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation.
Not available
S-EPMC5052622 | biostudies-literature
UnknownB-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunity.
Not available
S-EPMC3375897 | biostudies-literature
UnknownFunctional characterization of reappearing B cells after anti-CD20 treatment of CNS autoimmune disease.
Not available
S-EPMC6166805 | biostudies-literature
TranscriptomicsDifferential virulence gene expression in the pathogenic dermatophyte Arthroderma benhamiae in vitro versus infection
Although dermatophytes are the most common agents of superficial mycoses in humans and animals, the molecular basis of the pathogenicity of these fungi is largely unknown. In vitro digestion of keratin by dermatophytes is associated with the secretion of multiple proteases, which are assumed to be r...
ORGANISM(S): Arthroderma benhamiae 
2010-03-04 | E-GEOD-15873 | biostudies-arrayexpress
TranscriptomicsTranslation value of the bleomycin rat model for the treatment of patients with Idiopathic Pulmonary Fibrosis (IPF)
Intratracheal application of bleomycin is known to induce inflammatory and fibrotic reactions in the lung within a short period of time and histological features include infiltration of inflammatory cells, collagen deposition and obliteration of alveolar spaces. Because some of these features are fo...
ORGANISM(S): Rattus norvegicus 
2014-10-28 | E-GEOD-48455 | biostudies-arrayexpress
UnknownImproved darunavir genotypic mutation score predicting treatment response for patients infected with HIV-1 subtype B and non-subtype B receiving a salvage regimen.
Not available
S-EPMC5808835 | biostudies-literature
UnknownProline as a fuel for insect flight: enhancing carbohydrate oxidation in hymenopterans.
Not available
S-EPMC4947884 | biostudies-literature
UnknownHigh-dimensional single-cell analysis reveals the immune signature of narcolepsy.
Not available
S-EPMC5110028 | biostudies-literature
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