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TranscriptomicsAffymetrix data for training of Endopredict algorithm
These data, combined with other cohorts (GSE6532, GSE12093, and qRT-PCR based cohorts), was used to construct the EP algorithm, which predicts the likelihood of developing of a distant recurrence of early stage breast cancer under endocrine treatment. In addition, EPclin, a combination of the EP sco...
ORGANISM(S): Homo sapiens 
2011-10-10 | E-GEOD-26971 | biostudies-arrayexpress
TranscriptomicsRNAseq analysis of dose/dose rate response after gamma Co-60 exposure on C elegans larvae with focus on reproductive effects
This study investigated cellular events and transcriptomic alterations underlying reproductive defects caused by chronic gamma (γ) radiation in Caenorhabditis elegans (C. elegans). Continuous exposure (0, 1 mGy/h [total dose: 0.048 Gy], 10 mGy/h [total dose: 0.48 Gy] and 100 mGy/h; total dose: 4.8 G...
ORGANISM(S): Caenorhabditis elegans 
2025-11-30 | E-MTAB-15879 | biostudies-arrayexpress
ProteomicsPlasma and Extracellular Vesicle Proteomic Signatures of traumatic brain injury (TBI) in Polytrauma
This study aimed to identify TBI-specific proteomic signatures in a heterogeneous cohort of critically injured polytrauma patients by analyzing the total plasma proteome and an extracellular vesicle (EV)-enriched plasma protein fraction. Severely injured adult trauma patients (ISS ≥16) were allo...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD079127 | Pride
Traumatic brain injury  extracellular vesicles  biomarkers  proteomics  polytrauma 
ProteomicsMachine learning identifies clinical sepsis phenotypes that translate to the plasma proteome
Background: Sepsis therapy is still limited to the treatment of the underlying infection and supportive measures. Therapeutic options that address the molecular changes of sepsis have not yet been identified. With the aim of a future individualized therapy, we used unsupervised machine learning (ML)...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD058562 | Pride
Mass spectrometry Precision medicine Artificial intelligence Plasma Cluster analysis 
TranscriptomicsFIR inhibition in HCC cells (Hep3B)
siRNA-mediated inhibition compared to untreated cells and cells transfected with nonsense siRNA Together with far upstream element binding protein (FBP), the FBP-interacting repressor (FIR) represents a molecular tool for the transcriptional fine tune regulation of target genes. Previous evidence in...
ORGANISM(S): Homo sapiens 
2014-09-03 | E-GEOD-55692 | biostudies-arrayexpress
TranscriptomicsUptake and toxic mechanisms following chronic exposure to radium-224 dichloride in Caenorhabditis elegans
the study investigated effects of chronic α irradiation on somatic growth, fertility, germ cell apoptosis, reactive oxygen species (ROS) levels, and the transcriptomic mechanisms using the model organism Caenorhabditis elegans (C. elegans). Furthermore, chronic exposure to 224RaCl2 solutions, with a...
ORGANISM(S): Caenorhabditis elegans 
2026-10-16 | E-MTAB-17706 | biostudies-arrayexpress
TranscriptomicsConcurrent low-dose-rate gamma irradiation and inorganic arsenite in mice: genotoxicity and transcriptional responses in liver and testis in CBA and C57BL/6 mice
Mouse testis and liver samples collected one day post-radiation/As-exposure liver and testis genome-wide transcriptional profiles in male mice of two strains (CBA/CaOlaHsd and C57BL/6NHsd) exposed chronically to a low dose rate (2.5 mGy/h; 1200h, LDR), mid-dose rate (10 mGy/h; 300h, MDR), acutely to...
ORGANISM(S): Mus musculus 
2026-08-28 | E-MTAB-17355 | biostudies-arrayexpress
UnknownMachine learning identifies clinical sepsis phenotypes that translate to the plasma proteome.
Not available
S-EPMC12675651 | biostudies-literature
UnknownActivation of the MAPK network provides a survival advantage during the course of COVID-19-induced sepsis: a real-world evidence analysis of a multicenter COVID-19 Sepsis Cohort.
Not available
S-EPMC11825614 | biostudies-literature
UnknownPegaptanib sodium as maintenance therapy in neovascular age-related macular degeneration: the LEVEL study.
Not available
S-EPMC2991041 | biostudies-literature
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