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ProteomicsPupylation-independent substrate recruitment to proteasomal degradation in mycobacteria
Mycobacteria and other Actinobacteria possess proteasomal degradation pathways in addition to the common bacterial compartmentalizing protease systems. Proteasomal degradation supports survival of these bacteria in adverse environments and conditions. The mycobacterial proteasome interacts with mult...
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
2023-08-04 | PXD039021 | Pride
Heat shock Mycobacteria Quality control Proteasomal degradation 
TranscriptomicsRNA-seq of Mycobacterium smegmatis mc2-155 SMR5 wild-type vs. a pafBC deletion strain under different growth/stress conditions
The goal of the experiment is to obtain a differential gene expression profile for Mycobacterium smegmatis mc2-155 SMR5 (Msm) wild-type in comparison to a pafBC deletion strain (MSMEG_3888 and MSMEG_3889). In addition, the gene expression is to be analyzed with respect to different growth/stress con...
ORGANISM(S): Mycobacterium smegmatis str. MC2 155 
2018-06-17 | E-MTAB-6497 | biostudies-arrayexpress
GenomicsChIP-seq of Mycobacterium smegmatis PafBC to identify in vivo binding sites
We aimed to determine the binding sites of the putative transcriptional regulator PafBC under DNA damage stress induced by mitomycin C or under oxidative stress induced by hydrogen peroxide. Therefore, we chose a ChIP-seq approach, crosslinking cells before PafBC-DNA complexes were immunoprecipitate...
ORGANISM(S): Mycobacterium smegmatis str. MC2 155 
2018-06-17 | E-MTAB-6503 | biostudies-arrayexpress
UnknownStructure and functional implications of WYL domain-containing bacterial DNA damage response regulator PafBC.
Not available
S-EPMC6789036 | biostudies-literature
UnknownNovel WYL domain-containing transcriptional activator acts in response to genotoxic stress in rapidly growing mycobacteria.
Not available
S-EPMC10693628 | biostudies-literature
UnknownStructures of prokaryotic ubiquitin-like protein Pup in complex with depupylase Dop reveal the mechanism of catalytic phosphate formation.
Not available
S-EPMC8599861 | biostudies-literature
UnknownDepupylase Dop Requires Inorganic Phosphate in the Active Site for Catalysis.
Not available
S-EPMC5354516 | biostudies-literature
UnknownElectrostatic interactions guide substrate recognition of the prokaryotic ubiquitin-like protein ligase PafA.
Not available
S-EPMC10465538 | biostudies-literature
UnknownClpC2 protects mycobacteria against a natural antibiotic targeting ClpC1-dependent protein degradation.
Not available
S-EPMC10030653 | biostudies-literature
UnknownStructural basis of prokaryotic ubiquitin-like protein engagement and translocation by the mycobacterial Mpa-proteasome complex.
Not available
S-EPMC8755798 | biostudies-literature
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