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ProteomicsSera Protein Signatures of Endometrial Cancer Lymph Node Metastases
sera collected from endometrial cancer patients submitted to direct MS/MS analysis in diluted unprocessed form. MS only analysis of sera has also been performed. files are also available.
ORGANISM(S): Homo Sapiens (human) 
2022-03-17 | PXD031892 | JPOST Repository
TranscriptomicsTranscription profiling of human melanomas to assess metastatic potential defined by specific gene expression profiles with no BRAF signature
The molecular biology of metastatic potential in melanoma has been studied many times previously and changes in the expression of many genes have been linked to metastatic behaviour. What is lacking is a systematic characterization of the regulatory relationships between genes whose expression is re...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4840 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human melanomas to determine metastatic potential defined by specific gene expression profiles with no BRAF signature.
The molecular biology of metastatic potential in melanoma has been studied many times previously and changes in the expression of many genes have been linked to metastatic behaviour. What is lacking is a systematic characterization of the regulatory relationships between genes whose expression is re...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4845 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human melanomas to identify metastatic potential defined by specific gene expression profiles with no BRAF signature
The molecular biology of metastatic potential in melanoma has been studied many times previously and changes in the expression of many genes have been linked to metastatic behaviour. What is lacking is a systematic characterization of the regulatory relationships between genes whose expression is re...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4841 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human melanomas to assess metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature (Mannheim).
The molecular biology of metastatic potential in melanoma has been studied many times previously and changes in the expression of many genes have been linked to metastatic behaviour. What is lacking is a systematic characterization of the regulatory relationships between genes whose expression is re...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4843 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse primary macrophages treated with the chemotherapeutic agent, 5,6-dimethylxanthenone-4-acetic acid,
Vascular disrupting agents (VDA) represent a novel approach to the treatment of cancer, resulting in collapse of tumor vasculature and tumor death. 5,6-Dimethylxanthenone-4-acetic acid (DMXAA) is a VDA currently in advanced Phase II clinical trials, yet its precise mechanism of action is unknown de...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7194 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse immature pDC and pDC activated with CpG 1826 and influenza virus PR8
CpG 1826 binds to Toll-like receptor (TLR)9, whereas influenza virus PR8 activates pDC via TLR7. Differential stimulation of pDCs is expected to result in unique activation mechanism(s) leading to a different phenotypically and functionally matured pDC; We used microarrays to detail the global progr...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7831 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mpuse IL10-/- dendritic cells pulsed for 6h with 0, SEA, LPS, or co-pulsed with SEA/LPS together to compare changes in LPS-induced gene expression mediated by SEA (Schistosome soluble egg antigen)
IL10-/-DC pulsed for 6h with 0, SEA, LPS, or co-pulsed with SEA/LPS together to compare changes in LPS-induced gene expression mediated by SEA (Schistosome soluble egg antigen)
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-1382 | biostudies-arrayexpress
TranscriptomicsIQGAP1 Scaffold-Kinase Interaction Blockade Selectively Targets Ras-MAP Kinase Driven Tumors
MAPK scaffolds, such as IQGAP1, assemble pathway kinases together to effect signal transmission and disrupting scaffold function therefore offers a potentially orthogonal approach to MAPK cascade inhibition. Consistent with this possibility, we observed an IQGAP1 requirement in Ras-driven tumorigene...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-44967 | biostudies-arrayexpress
TranscriptomicsImatinib Disrupts Lymphoma Angiogenesis by Targeting Vascular Pericytes
Pericytes/vascular smooth muscle cells (VSMCs), regulated by platelet-derived growth factor receptor β (PDGFRβ) signaling, play important roles in endothelial survival and vascular stability. Here we report that treatment with imatinib, an inhibitor of PDGFRβ, led to significant tumor growth impairm...
ORGANISM(S): Mus musculus 
2013-04-22 | E-GEOD-30752 | biostudies-arrayexpress
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