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ProteomicsCD49f defines a subset of dysfunctional regulatory T cells circulating in the human peripheral blood
The therapeutic use of regulatory T cells (Tregs) in patients with autoimmune disorders has been hampered by the biological variability of memory Treg populations in the peripheral blood. In this study, we reveal through a combination of quantitative proteomic, multiparametric flow cytometry, RNA-se...
ORGANISM(S): Homo sapiens (Human) 
2021-08-06 | PXD022095 | Pride
Human Regulatory t cells Shotgun proteomics 
ProteomicsA primary human T-cell spectral library to facilitate large scale quantitative T-cell proteomics
A primary human T-cell spectral library to facilitate large scale quantitative T-cell proteomics
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD019542 | Pride
Human t-cells Swath-ms Proteomics 
ProteomicsA primary human T-cell spectral library to facilitate large scale quantitative T-cell proteomics
Comprehensive spectral libraries are essential in sequential window acquisition of all theoretical mass spectra (SWATH-MS) based high throughput proteomic studies. Even though SWATH-MS assays provide robust quantitative proteomics data its applications to human T-cell studies are limited by the lack...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD019446 | Pride
Human Swath Spectral library Primary t-cells 
ProteomicsIntegrative proteomics and transcriptomics of human T-cells reveals temporal changes in metabolic pathways following TCR-mediated activation
T-cells are a critical component of the adaptive immune system and play a key role in immunological surveillance. Upon engagement of T-cell receptor (TCR), CD4+ and CD8+ T-cells acquire effector functions through a complex interplay between mRNA and proteins yet to be fully understood. In this study...
ORGANISM(S): Homo sapiens (Human) 
2023-12-28 | PXD038810 | Pride
Human t cell activation Dda proteomics Cd8+ t cells Cd4+ t cells 
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