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We describe the epigenetic profiling of the H3K9me2 and HP1a in Drosophila third instar larvae before and after CDK12 depletion by RNA interference (RNAi). Here we show that CDK12 regulates heterochromatin dynamics in Drosophila chromosomes. Depletion of CDK12 induces the increased HP1a and H3K9me2 ...
ORGANISM(S): Drosophila melanogaster 
Protein post-translational modifications (PTMs), such as acetylation and methylation, are established as crucial epigenetic marks in eukaryotic cells. Recent advances in mass spectrometry have led to the discovery of novel PTMs, including crotonylation, 2-hydroxyisobutyrylation, β-hydroxybutyrylatio...
ORGANISM(S): Oryza sativa (Rice) 
2026-03-09 | PXD059709 | Pride
Protein post-translational modifications (PTMs), such as acetylation and methylation, are established as crucial epigenetic marks in eukaryotic cells. Recent advances in mass spectrometry have led to the discovery of novel PTMs, including crotonylation, 2-hydroxyisobutyrylation, β-hydroxybutyrylatio...
ORGANISM(S): Oryza sativa (Rice) 
2026-03-09 | PXD059711 | Pride
The testis tissue-based trans-omics was a feasible approach to find more missing proteins (MPs) because it was reported higher gene expression found in testis tissues. Three testis tissues and two protein separation strategies were selected to quantitatively evaluate gene expression abundance at the...
ORGANISM(S): Homo sapiens (Human) 
2015-11-03 | PXD002179 | Pride
Transcription factor Ebf1 is an important determinant of early B lymphopoiesis. To gain insight into differentiation stage-specific functions of Ebf1, we conditionally inactivated Ebf1. We found that Ebf1 is required for proliferation, survival and signaling of pro-B cells and peripheral B cell su...
ORGANISM(S): Mus musculus 
Protein palmitoylation, also known as S-acylation, is a reversible post-translational modification in which fatty acids are covalently attached to cysteine residues via thioester bonds. To date, protein palmitoylation has been well studied in animal cells, where it plays a crucial role in regulating...
ORGANISM(S): Oryza sativa (Rice) 
2026-02-13 | PXD060133 | Pride
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