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ProteomicsProximity proteomics of endothelial Weibel-Palade bodies identifies novel regulator of VWF secretion
Weibel-Palade bodies (WPB) are unique secretory organelles of endothelial cells that store factors regulating vascular haemostasis and local inflammation. Endothelial activation triggers the acute exocytosis of WPB, leading to the surface presentation of adhesion molecules relevant for leukocyte rol...
ORGANISM(S): Homo sapiens (Human) 
2019-07-11 | PXD013194 | Pride
Lc-msms Weibel-palade bodies Von-willebrand factor Endothelial cells Proximity labeling Human Biotinylation 
ProteomicsSyntaxin 5 determines Weibel-Palade body size and Von Willebrand factor secretion by controlling Golgi architecture
Abstract Von Willebrand factor (VWF) is a multimeric hemostatic protein primarily synthesized in endothelial cells (ECs). VWF is stored in endothelial storage organelles, the Weibel-Palade bodies (WPBs), whose biogenesis strongly depends on VWF anterograde trafficking and Golgi architecture. Elongat...
ORGANISM(S): Homo sapiens (Human) 
2022-01-27 | PXD027516 | Pride
Human Endothelial cells Weibel-palade bodies Von willebrand factor 
UnknownRegulatory components of the alternative complement pathway in endothelial cell cytoplasm, factor H and factor I, are not packaged in Weibel-Palade bodies.
Not available
S-EPMC4372330 | biostudies-literature
ProteomicsDefective AP-3-dependent VAMP8 trafficking impairs Weibel-Palade body exocytosis in Hermansky-Pudlak Syndrome type 2 blood outgrowth endothelial cells.
Weibel-Palade bodies (WPBs) are endothelial secretory organelles that contain VWF, P-selectin and CD63. Release of VWF from WPBs is crucial for platelet adhesion during primary hemostasis. Endosomal trafficking of proteins like CD63 to WPBs during maturation is dependent on the AP-3 complex. Mutatio...
ORGANISM(S): Homo sapiens (Human) 
2019-01-31 | PXD011294 | Pride
Endothelial cells Weibel-palade bodies Hps2 Ap3 complex 
UnknownStimulated release of intraluminal vesicles from Weibel-Palade bodies.
Not available
S-EPMC6624784 | biostudies-literature
ProteomicsInteraction networks of Weibel-Palade body regulators syntaxin-3 and syntaxin binding protein 5 in endothelial cells
The endothelium stores the hemostatic protein Von Willebrand factor (VWF) in endothelial storage organelles called Weibel-Palade bodies (WPBs). During maturation, WPBs recruit a complex of Rab GTPases and effectors that associate with components of the SNARE machinery that control WPB exocytosis. Re...
ORGANISM(S): Homo sapiens (Human) 
2023-01-06 | PXD012809 | Pride
Weibel-palade body  snare protein  syntaxin  protein-protein interactions 
UnknownFactor VIII Is Synthesized in Human Endothelial Cells, Packaged in Weibel-Palade Bodies and Secreted Bound to ULVWF Strings.
Not available
S-EPMC4608722 | biostudies-literature
UnknownProtein mobilities and P-selectin storage in Weibel-Palade bodies.
Not available
S-EPMC2923571 | biostudies-literature
UnknownStructural organization of Weibel-Palade bodies revealed by cryo-EM of vitrified endothelial cells.
Not available
S-EPMC2765093 | biostudies-literature
UnknownRab35 protein regulates evoked exocytosis of endothelial Weibel-Palade bodies.
Not available
S-EPMC5512060 | biostudies-literature
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