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UnknownIL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation.
Not available
S-EPMC4939696 | biostudies-literature
TranscriptomicsmiR-155 plays a crucial role in ALS and is an immune therapeutic target [RNA-Seq]
Amyotrophic lateral sclerosis (ALS) is a paralytic degenerative disease of the nervous system. In the SOD1 mouse model of ALS we found loss of the molecular and functional microglia signature associated with pronounced expression of miR-155 in SOD1 mice. We also found increased expression of miR-155...
ORGANISM(S): Homo sapiens 
2014-11-24 | E-GEOD-52946 | biostudies-arrayexpress
TranscriptomicsInfluence of Interferon-beta on expression profile of memory T-cells
Inflammasomes are multi-protein complexes that control the production of pro-inflammatory cytokines such as IL-1beta. Inflammasomes play an important role in the control of immunity to tumors and infections, and also in autoimmune diseases, but the mechanisms controlling the activation of human infl...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-35601 | biostudies-arrayexpress
TranscriptomicsMG400 profile of microglia from SOD miR155-KO mice
Amyotrophic lateral sclerosis (ALS) is a paralytic degenerative disease of the nervous system. In the SOD1 mouse model of ALS we found loss of the molecular and functional microglia signature associated with pronounced expression of miR-155 in SOD1 mice. We also found increased expression of miR-155...
ORGANISM(S): Mus musculus 
2014-11-24 | E-GEOD-52803 | biostudies-arrayexpress
UnknownTargeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.
Not available
S-EPMC4432483 | biostudies-literature
UnknownAncestral risk modification for multiple sclerosis susceptibility detected across the Major Histocompatibility Complex in a multi-ethnic population.
Not available
S-EPMC9778564 | biostudies-literature
UnknownAcute microglia ablation induces neurodegeneration in the somatosensory system.
Not available
S-EPMC6212411 | biostudies-literature
UnknownMeta-analysis identifies common gut microbiota associated with multiple sclerosis.
Not available
S-EPMC11293023 | biostudies-literature
GenomicsBrigham and Women's Hospital Multiple Sclerosis Genetic Collection

The main objective of this GWA study is to identify Multiple Sclerosis (MS) susceptibility loci. Whole-genome association analysis was performed on 924 individuals genotyped on the Affymetrix 6.0 Genechip. The cohort consisted of 860 clinically diagnosed MS patients and 64 control subjects.

phs000275.v1.p1 | EGA
TranscriptomicsTranscription profiling of human peripheral blood from relapsing-remitting MS patients either untreated or treated with glatiramer acetate or interferon beta
One of our new major finding among the genes that contributes to MS susceptibility is ICSBP1. The so called disease modifying therapies like interferon-beta (IFN-β), possibly acting on the peripheral T-cells, reduce the disease activity and the clinical progression, with a MRI-detectable effect in ...
ORGANISM(S): Homo sapiens 
2009-08-09 | E-GEOD-16214 | biostudies-arrayexpress
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