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TranscriptomicsVitamin C Stimulon in Mycobacterium tuberculosis
The emergence of drug resistance among tuberculosis (TB) patients is often associated with their non-compliance to the length of the chemotherapy, which can reach up to 2 years for the treatment of multi-drug-resistant (MDR) TB. Drugs that would kill TB faster and would not lead to the development ...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2013-05-24 | E-GEOD-42293 | biostudies-arrayexpress
TranscriptomicsTranscriptional Response of Mycobacterium tuberculosis to Growth without Detergent
Transcriptional profiling of Mycobacterium tuberculosis H37Rv grown in minimal media with or without detergent for 5 days to investigate basis of differences in vaccine efficacy dependent on growth conditions Two condition experiment, detergent grown vs. grown without detergent. Biological replicate...
ORGANISM(S): Mycobacterium tuberculosis 
2016-05-31 | E-GEOD-72745 | biostudies-arrayexpress
TranscriptomicsNicotinamide Starvation of Mycobacteria Defective for de novo NAD Biosynthesis
Mycobacteria can synthesize NAD+ using either the de novo biosynthesis pathway or the salvage pathway. The deletion of the three genes involved specifically in the NAD+ de novo biosynthesis pathway in the human pathogen Mycobacterium tuberculosis had no effect on the growth of the strain in vivo. ...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-14 | E-GEOD-18909 | biostudies-arrayexpress
TranscriptomicsMaltose-1-Phosphate Stress Stimulon in Mycobacterium tuberculosis
New chemotherapeutics are urgently required to control the tuberculosis pandemic fueled by the emergence of multidrug- and extensively-drug-resistant Mycobacterium tuberculosis strains and the bacterium`s catastrophic alliance with HIV. Here we describe a novel trehalose-to-α-glucan pathway in M. t...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-14 | E-GEOD-18575 | biostudies-arrayexpress
TranscriptomicsTCA1 Stimulon in Mycobacterium tuberculosis
A cell-based phenotypic screen for inhibitors of biofilm formation in Mycobacterium tuberculosis (Mtb) identified the small molecule TCA1, which has bactericidal activity against both drug susceptible and drug resistant Mtb, and synergizes with rifampicin (RIF) or isoniazid (INH) in sterilization of...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2013-05-24 | E-GEOD-42151 | biostudies-arrayexpress
TranscriptomicsTranscriptome of phosphomimetic and phosphoablative kasB mutants of Mycobacterium tuberculosis
Mechanisms governing Mycobacterium tuberculosis acid-fastness and its capacity to induce long-term infections remain unknown. Serine/Threonine phosphorylation represents an emerging theme allowing mycobacteria to adapt their cell envelope structure/composition in response to environmental changes. W...
ORGANISM(S): Mycobacterium tuberculosis 
2014-04-01 | E-GEOD-47640 | biostudies-arrayexpress
TranscriptomicsPellicle Stimulon in Mycobacterium tuberculosis
Triplicate 10mL cultures of M. tuberculosis grown in Sautons media without detergent in planktonic (exponential growth phase at OD600 0.2) compared to pellicle (3 weeks growth without shaking in 5% CO2) conditions. comparison of pellicle growth transcriptome to planktonic growth transcriptome, 3 bio...
ORGANISM(S): Mycobacterium tuberculosis 
2013-05-24 | E-GEOD-37392 | biostudies-arrayexpress
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