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ProteomicsSecreted parasite Pin1 isomerase stabilizes host PKM2 to reprogram host cell metabolism
Metabolic reprogramming is an important feature of host-pathogen interactions and a hallmark of tumorigenesis. The intracellular apicomplexa parasite Theileria induces a Warburg-like effect in host leukocytes by hijacking signaling machineries, epigenetic regulators and transcriptional programs to c...
ORGANISM(S): Homo sapiens (Human) 
2019-11-13 | PXD012895 | Pride
Ls-ms/ms Pin1 Pkm 
ProteomicsTheileria parasites sequester host eIF5a to escape elimination by host-mediated autophagy
Intracellular pathogens develop elaborate mechanisms to survive within the hostile environments of host cells. Theileria parasites infect bovine leukocytes and cause devastating diseases in cattle in developing countries. Theileria spp. have evolved sophisticated strategies to hijack host leukocytes...
ORGANISM(S): Theileria annulata 
2024-05-24 | PXD047937 | Pride
Drug screening Epigenetic inhibitor Parasite host response Theileria Protein sequestration Autophagy 
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