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TranscriptomicsPin1 is required for sustained B cell proliferation upon oncogenic activation of Myc
The c-myc proto-oncogene is activated by translocation in Burkitt's lymphoma and substitutions in codon 58 stabilize the Myc protein or augment its oncogenic potential. In wild-type Myc, phosphorylation of Ser 62 and Thr 58 provide a landing pad for the peptidyl prolyl-isomerase Pin1, which in turn ...
ORGANISM(S): Mus musculus 
2016-06-14 | E-GEOD-77482 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of mRNA levels in response to a Pin1 knock-down
Pin1 is a prolyl isomerase that plays an important role in cancer, Alzheimer's disease, and asthma. To understand how Pin1 levels affect mRNA abundance on a genome-wide scale, we knocked down Pin1 by siRNA and used microarray-based gene expression profiling to identify candidate genes that are signi...
ORGANISM(S): Homo sapiens 
2012-10-27 | E-GEOD-41868 | biostudies-arrayexpress
TranscriptomicsPin1/mutant-p53 jointly controlled genes
To investigate the specific gene expression program by which mutant-p53 and Pin1 control invasion and metastasis in breast cancer cells, we compared the transcriptomic profile of control, mutant-p53 depleted or Pin1 depleted MDA-MB-231 cells. MDA-MB-231 cells were transfected twice with siRNA agains...
ORGANISM(S): Homo sapiens 
2011-05-30 | E-GEOD-26262 | biostudies-arrayexpress
TranscriptomicsExpression data from Pin1 inhibitor ATRA and Pin1 knockdown
ATRA was identified as a Pin1 inhibitor via fluorescence polarization-based high throughput screening. We performed microarray expression profiling to demonstrate the similarity between ATRA and Pin1 KD at the genome-wide level APL NB4 cells in response to ATRRA or inducible Pin1 knockdown for 3 da...
ORGANISM(S): Homo sapiens 
2015-04-12 | E-GEOD-63059 | biostudies-arrayexpress
TranscriptomicsExpression data from prostate cancer cell lines LNCap (androgen dependent) and DU145 (androgen independent), transfected with Pin1 or control siRNA
Pin1 inhibiton exerts anti-oncogenic effects on LNCaP and DU145 cells despite the gene regulation patterns by Pin1 were different in both cells. We investigated how Pin1 modulates the gene expressions in the androgen-dependent as well as the androgen-independent prostate cancer cell lines For the kn...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-67457 | biostudies-arrayexpress
ProteomicsSubstrate selectivity for semisynthetic CK2 proteins with Pin1
Protein Ser/Thr kinase CK2 is involved in a myriad of cellular processes including cell growth and proliferation by phosphorylating hundreds of substrates, yet the regulation process of CK2 function is poorly understood. The CK2 catalytic subunit, CK2α, is phosphorylated at Thr344 and phosphorylati...
ORGANISM(S): synthetic construct 
2011-10-24 | E-GEOD-33150 | biostudies-arrayexpress
TranscriptomicsA novel post-translational mechanism controlling the oncogenic activity of c-Myc is enhanced in poor outcome breast cancer
Examination of Pin1-regulated Myc target genes in a human breast epithelial cell line. Two samples: control GFP-expressing MCF10A-Myc cells and Pin1-expressing MCF10A-Myc cells.
ORGANISM(S): Homo sapiens 
2014-05-28 | E-GEOD-33776 | biostudies-arrayexpress
ProteomicsStabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells to augment glioblastoma malignancy
he unique prolyl isomerase Pin1 that promotes protein conformational changes is a pivotal therapeutic target in many cancers, but little is known about the regulation of Pin1 protein stability. We previously found that Pin1 was highly expressed in glioma stem cells (GSCs) relative to non-stem tumor ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD041043 | Pride
Deubiquitination Ls-ms/ms Pin1 
ProteomicsArsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells
Arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) combination safely cures fatal acute promyelocytic leukemia, but the mechanisms underlying their action and synergy remain elusive. ATRA inhibits APL, breast and liver cancers by targeting isomerase Pin1, a master regulator of oncogenic signa...
ORGANISM(S): Homo sapiens (Human) 
2018-10-16 | PXD010224 | Pride
Ato Atra Synergy Pin1 
ProteomicsProteomic analysis of the physiological E3 ubiquitin ligase responsible for PIN1 degradation
Induced oncoproteins degradation provides an attractive anti-cancer modality. Activation of anaphase-promoting complex (APC/CCDH1) prevents cell cycle entry by targeting crucial mitotic proteins for degradation. Phosphorylation of its co-activator CDH1 modulates the E3 ligase activity, but little is...
ORGANISM(S): Homo sapiens (Human) 
2024-02-28 | PXD046325 | Pride
Pin1 Proteomics Cdh1 
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