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TranscriptomicsSingle cell analysis of the Common Lymphoid Progenitor compartment reveals functional and molecular heterogeneity
In order to investigate molecular events involved in the regulation of lymphoid lineage commitment, we crossed lamda5 reporter transgenic mice to mice where the GFP gene is inserted into the Rag1 locus. This allowed us to sub-fractionate common lymphoid progenitors (CLPs) and pre-pro-B cells into la...
ORGANISM(S): Mus musculus 
2009-11-24 | E-GEOD-19142 | biostudies-arrayexpress
TranscriptomicsA global network of transcription factors, involving E2A, EBF1 and FOXO1, that orchestrates the B cell fate
It is now established that the transcription factors E2A, EBF1 and FoxoM-BM- 1 play critical roles in B cell development. Here we show that E2A and EBF1 bound regulatory elements present in the Foxo1 locus. E2A and EBF1 as well as E2A and Foxo1, in turn, were wired together by a vast spectrum of cis...
ORGANISM(S): Mus musculus 
2010-06-12 | E-GEOD-21978 | biostudies-arrayexpress
TranscriptomicsExpression data from WT, HEB-KO and E2A-KO LY6D- CLP cells
The E-protein transcription factors E2A and HEB play important roles at several stages of hematopoiesis. However, the exact mechanism for theire action and the main targets in the LY6D negative common lymphoid progentior (CLP) compartment remains unknown. By adressing this question, we will gain imp...
ORGANISM(S): Mus musculus 
2011-11-22 | E-GEOD-27402 | biostudies-arrayexpress
TranscriptomicsExpression profiling of ProB and PreB cells in Ebf1 heterozygous mouse bone marrow
Loss of one allele of Ebf1 impairs pre-B cell (B220+CD19+CD43low/negIgM-) expansion. In order to better understand the underlying cause of the reduced pre-B cell compartment in Ebf1+/- mice, we sorted pro-B (B220+CD19+CD43highIgM- ) as well as pre-B cells from Wt and Ebf1 heterozygote mutant mice an...
ORGANISM(S): Mus musculus 
2013-10-18 | E-GEOD-51385 | biostudies-arrayexpress
OtherA Protein Deep Sequencing Evaluation of Metastatic Melanoma Tissues.
Data from ProteomeXchange, .PXD ID: PXD001724. Experiment: M35_003, file: folder summary. Published as part of PLoS One. 2015 Apr 13;10(4):e0123661 . From the Abstract: {{i}} ... The aim of the present study was to build a protein sequence database in metastatic melanoma, searching for novel, relev...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310019253 | GPMDB
Resource Reanalysis 
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