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TranscriptomicsGene expression after 24h Urolithin A incubation in LNCaP cells
The identification of new agents that may modulate the progression of cancer cell growth is of great interest. In this regard, dietary agents can be utilized to identify molecular targets to be used as part of a chemopreventive strategy. Walnuts contain several bioactive compounds, including peduncu...
ORGANISM(S): Homo sapiens 
2016-07-27 | E-GEOD-65527 | biostudies-arrayexpress
ProteomicsAn automated workflow for label-free and multiplexed single cell proteomics sample preparation at unprecedented sensitivity.
The analysis of single cell proteomes has recently become a viable complement to transcript and genomics studies. Proteins are the main driver of cellular functionality and mRNA levels are often an unreliable proxy of such. Therefore, the global analysis of the proteome is essential to study cellula...
ORGANISM(S): Homo sapiens (Human) 
2021-04-19 | PXD025387 | Pride
Single cell proteomics Proteochip Label-free Multiplexed 
TranscriptomicsTranscription profiling of mouse liver with CEBPa wild type and knockout animals.
Expression analysis of CEBPa knockout effects on gene expression in adult mouse liver. We used a conditional knock out strategy to delete CEBPa specifically in adult mouse hepatocytes and analysed the resulting changes in gene expression by means of microarrays.
ORGANISM(S): Mus musculus 
2010-04-08 | E-MTAB-178 | biostudies-arrayexpress
TranscriptomicsRNA-seq of SARS-CoV-2-infected human primary hepatocyte-derived spheroids upon interferon a2 and baricitinib treatment
Biological replicates of liver spheroids derived from primary hepatocytes were treated with IFNa2 and/or baricitinib for 24 h and subsequently infected with Sars-CoV-2. The cells were harvested 48 h time after infection. Total RNA was extracted and sequenced with a strand-specific paired end RNA-seq...
ORGANISM(S): Homo sapiens 
2020-11-18 | E-MTAB-9711 | biostudies-arrayexpress
UnknownAmyloid-β disrupts APP-regulated protein aggregation and dissociation from recycling endosomal membranes
Not available
S-SCDT-10_1038-S44318-025-00497-Y | biostudies-other
TranscriptomicsThe PIN domain endonuclease Utp24 cleaves pre-ribosomal RNA at two coupled sites in yeast and humans
Purpose: Pre-ribosomal RNA is cleaved at defined sites, but many endonucleases involved in 18S rRNA release are not known. We apply an in vivo cross-linking technique coupled with deep sequencing (CRAC) that captures transcriptome-wide interactions between a yeast candidate pre-rRNA endonuclease (Ut...
ORGANISM(S): Saccharomyces cerevisiae 
2016-04-01 | E-GEOD-75991 | biostudies-arrayexpress
TranscriptomicsWhole-exome sequencing identifies mutations of BCOR in acute myeloid leukemia with normal karyotype
Among acute myeloid leukemias (AML) with normal karyotype (CN-AML), NPM1 and CEBPA mutations define WHO provisional entities accounting for ~60% of cases, but the remaining ~40% remains poorly characterized. By whole exome-sequencing (WES) of one CN-AML patient lacking mutations in NPM1, CEBPA, FLT3...
ORGANISM(S): Homo sapiens 
2011-12-16 | E-GEOD-30442 | biostudies-arrayexpress
TranscriptomicsMycobacterial cells have dual nickel-cobalt sensors: sequence-relationships and metal-sites of metal-responsive repressors are not congruent.
A novel ArsR-SmtB family transcriptional repressor, KmtR, has been characterised from mycobacteria. Mutants of M. tuberculosis lacking kmtR show elevated expression of Rv2025c encoding a deduced CDF-family metal-exporter. KmtR-dependent repression of the cdf and kmtR operator-promoters was alleviate...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-17 | E-BUGS-49 | biostudies-arrayexpress
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