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ProteomicsAn automated workflow for label-free and multiplexed single cell proteomics sample preparation at unprecedented sensitivity.
The analysis of single cell proteomes has recently become a viable complement to transcript and genomics studies. Proteins are the main driver of cellular functionality and mRNA levels are often an unreliable proxy of such. Therefore, the global analysis of the proteome is essential to study cellula...
ORGANISM(S): Homo sapiens (Human) 
2021-04-19 | PXD025387 | Pride
Single cell proteomics Proteochip Label-free Multiplexed 
ProteomicsAn automated and fast sample preparation workflow for laser microdissection guided ultrasensitive proteomics
Spatial tissue proteomics integrating whole-slide imaging, laser microdissection and ultrasensitive mass spectrometry is a powerful approach to link cellular phenotypes to functional proteome states in (patho)physiology. To be applicable to large patient cohorts and low sample input amounts, includi...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-03-22 | PXD047762 | Pride
Spatial proteomics Mass spectrometry Tissue proteomics Sample preparation Robotics 
ProteomicsDeep single-cell proteomics quantifies low-abundant embryonic transcription factors and lineage markers during induced pluripotent stem cell differentiation
Single-cell proteomics (SCP) promises to revolutionize biomedicine by providing an unparalleled view of the proteome in individual cells. Here, we present a high-sensitivity SCP workflow identifying >5000 proteins in individual HeLa cells. It also facilitated direct detection of post-translational m...
ORGANISM(S): Homo sapiens (Human) 
2024-08-17 | PXD049211 | Pride
Single-cell proteomics Proteochip evo 96 Orbitrap astral 
ProteomicsDeep single-cell proteomics quantifies low-abundant embryonic transcription factors and lineage markers during induced pluripotent stem cell differentiation
Single-cell proteomics (SCP) promises to revolutionize biomedicine by providing an unparalleled view of the proteome in individual cells. Here, we present a high-sensitivity SCP workflow identifying >5000 proteins in individual HeLa cells. It also facilitated direct detection of post-translational m...
ORGANISM(S): Homo sapiens (Human) 
2024-08-17 | PXD049181 | Pride
Single-cell proteomics Proteochip evo 96 Orbitrap astral 
UnknownAn Automated Nanowell-Array Workflow for Quantitative Multiplexed Single-Cell Proteomics Sample Preparation at High Sensitivity.
Not available
S-EPMC10684380 | biostudies-literature
UnknownAutomated single-cell proteomics providing sufficient proteome depth to study complex biology beyond cell type classifications.
Not available
S-EPMC10849471 | biostudies-literature
UnknownAn Automated and Fast Sample Preparation Workflow for Laser Microdissection Guided Ultrasensitive Proteomics.
Not available
S-EPMC11067455 | biostudies-literature
ProteomicsDeep single-cell proteomics quantifies low-abundant embryonic transcription factors and lineage markers during induced pluripotent stem cell differentiation
Single-cell proteomics (SCP) promises to revolutionize biomedicine by providing an unparalleled view of the proteome in individual cells. Here, we present a high-sensitivity SCP workflow identifying >5000 proteins in individual HeLa cells. It also facilitated direct detection of post-translational m...
ORGANISM(S): Homo sapiens (Human) 
2024-08-17 | PXD054066 | Pride
Single-cell proteomics 
ProteomicsDeciphering lineage specification during early embryogenesis using multi-layered proteomics
Gastrulation is a critical stage in embryonic development during which the germ layers are established. The advances and increasing availability of sequencing technologies led to the identification of gene regulatory programs that control the emergence of the germ layers and its derivatives. However...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-05 | PXD048347 | Pride
Proteomics Dtag system Interaction proteomics Enhancers Zeb2 Transcription factors Somitoids Gastruloids Developmental biology 
ProteomicsDeciphering lineage specification during early embryogenesis using multi-layered proteomics
Gastrulation is a critical stage of embryonic development during which the three germ layers are established. Deciphering the molecular mechanisms underlying this process from a protein perspective remains a significant challenge. To address this, we employed a multilayered mass spectrometry-based p...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-05 | PXD041328 | Pride
Proteomics Dtag system Interaction proteomics Enhancers Zeb2 Transcription factors Somitoids Gastruloids Developmental biology 
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