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infarct size and subsequent deterioration in function. The identification of factors that enhance cardiac repair by the restoration of the vascular network is, therefore, of great significance. Here, we show that the transcription factor Zinc finger E-box-binding homeobox 2 (ZEB2) is increased in st...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-03-23 | PXD022212 | Pride
Study of loss of ZEB2 in breast cancer cells in vitro and in vivo: gene expression and phenotypic switch to more benign behavior of the cancer cells. Morphological, functional and gene microarray analysis following ZEB2 knockdown in MDAMB231 cells reveals gain of epithelial differentiation, reductio...
ORGANISM(S): Homo sapiens 
To test the differences in chromatin accessibility of spleen B cells between Zeb2-CKO mice and WT mice, we isolated naive B cells from B cell-specific Zeb2-CKO and WT mice and cultured them in ABC-inducing culture for 3 days and performed ATAC assay.
ORGANISM(S): Mus musculus 
ZEB2 locus regulation in differentiating iPSCs
To clarify the regulation of Zeb2 and T-bet in ABCs, we used flow cytometry to sort 50 million mouse age-associated B cells and perform Cut&RUN assay.
ORGANISM(S): Mus musculus 
cMaf supports Zeb2 expression for primitive hematopoiesis (Multiome)
Zeb2 regulates myogenic differentiation in pluripotent stem cells
To elucidate the mechanisms of rapid progression of serous ovarian cancer, gene expression profiles from forty-three ovarian cancer tissues comprising eight early stage and thirty-five advanced stage tissues were performed using oligonucleotide microarrays of 18,716 genes. By non-negative matrix fac...
ORGANISM(S): Homo sapiens 
cMaf supports Zeb2 expression for primitive hematopoiesis (CUT&RUN)
We have demonstrated that the oncogenic activation of B-RAF (using a truncated delta-BRAF-ER version inducible with tamoxifen) in the melan-a melanocyte cell line triggers the activation of Zeb1 and Twist1 at the expanse of Zeb2 and Snail2. Enforced maintenance of Zeb2 or Snail2 expression reduces t...
ORGANISM(S): Mus musculus 
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