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ProteomicsMultiplexed CuAAC-Suzuki-Miyaura for tandem activity-based chemoproteomic profiling
Suzuki-Miyauara cross-coupling has been used for mass-spectrometry-based chemoproteomics, including for target deconvolution and site of labeling studies. We also demonstrated that Suzuki-Miyauara cross coupling and CuAAC can be combined for dual target labeling for mass spectrometry-based proteomic...
ORGANISM(S): Homo sapiens (Human) 
2021-02-03 | PXD022279 | Pride
Multiplexed cuaac suzuki-miyaura chemoproteomics Sp3 cleanup Suzuki-miyauara cross-coupling 
ProteomicsMultiplexed isobaric quantitative Protein Interaction Reporter (iqPIR) cross-linking on standard proteins
Initial demonstration of multiplexed isobaric quantitative Protein Interaction Reporter technology using two multiplexed samples consisting of 5 cross-linked standard proteins including alcohol dehydrogenase 1 (ADH1_YEAST), albumin (ALBU_BOVIN), cytochrome c (CYC_BOVIN), hemoglobin (HBA_HUMAN), and ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) Equus caballus (Horse) 
2023-03-11 | PXD026037 | Pride
Multiplexed quantitation Cross-linking mass spectrometry 
ProteomicsAn automated workflow for label-free and multiplexed single cell proteomics sample preparation at unprecedented sensitivity.
The analysis of single cell proteomes has recently become a viable complement to transcript and genomics studies. Proteins are the main driver of cellular functionality and mRNA levels are often an unreliable proxy of such. Therefore, the global analysis of the proteome is essential to study cellula...
ORGANISM(S): Homo sapiens (Human) 
2021-04-19 | PXD025387 | Pride
Single cell proteomics Proteochip Label-free Multiplexed 
ProteomicsMultiplexed Quantitative Proteomics Provides Mechanistic Cues for Malaria Severity and Complexity
Management of severe malaria remains a critical global challenge. In this study, using a multiplexed quantitative proteomics pipeline we systematically investigated the plasma proteome alterations in non-severe and severe malaria patients. We identified a few parasite proteins in severe malaria pati...
ORGANISM(S): Homo sapiens (Human) 
2020-11-06 | PXD014991 | Pride
Multiplexed quantitative proteomics Severe malaria Infectious disease 
GenomicsMultiplexed identification of the genomic targets of DNA-binding proteins
Transcription factors direct gene expression, and so there is much interest in mapping their genome-wide binding locations. M-BM- Current methods do not allow for the multiplexed analysis of TF binding, and this limits their throughput. We describe a novel method for determining the genomic target g...
ORGANISM(S): Saccharomyces cerevisiae 
2011-02-18 | E-GEOD-27381 | biostudies-arrayexpress
ProteomicsFull-featured, real-time database searching platform enables fast and accurate multiplexed quantitative proteomics.
Multiplexed quantitative analyses of complex proteomes enable deep biological insight. While a multitude of workflows have been developed for multiplexed analyses, the most quantitatively accurate method (SPS-MS3) suffers from long acquisition duty cycles. We built a new, real-time database search (...
ORGANISM(S): Homo sapiens (Human) 
2020-04-09 | PXD017823 | Pride
Multiplexed Orbiter Real-time search 
TranscriptomicsMultiplexed RNA structure characterization with selective 2'-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq)
New regulatory roles continue to emerge for both natural and engineered noncoding RNAs, many of which have specific secondary and tertiary structures essential to their function. Thus there is a growing need to develop technologies that enable rapid characterization of structural features within com...
ORGANISM(S): Bacillus subtilis 
2011-08-26 | E-GEOD-31573 | biostudies-arrayexpress
ProteomicsLibrary-Based, Multiplexed Strategy for Mapping Protein Interaction Networks via Crosslinking
Protein-protein interactions are fundamental to cellular function, yet resolving their interaction interfaces and dynamic behaviors in native biological contexts remains challenging, particularly for weak or transient interactions. Crosslinking strategies based on noncanonical amino acids offer an e...
ORGANISM(S): Homo Sapiens 
2026-02-28 | PXD075032 |
GenomicsMultiplexed Perturbation Enables Scalable Pooled Screens
Multiplexed Perturbation Enables Scalable Pooled Screens
PRJNA1290110 | ENA
ProteomicsYeast Multiplexed HyCCAPP
Bottom-up proteomics data from a study of proteins associated with yeast's ribosome biogenesis and stress response genes (four genomic loci: 25S rDNA, ARX1, CTT1 and RPL30), using multiplexed HyCCAPP (Hybridization Capture of Chromatin-Associated Protein for Proteomics). Data include spectra from 4 ...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2017-05-08 | MSV000081066 | MassIVE
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