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TranscriptomicsPyrococcus furiosus crRNAs associated with Cmr, Csa and Cst CRISPR-Cas systems
CRISPR-Cas immune systems function to defend prokaryotes against potentially harmful mobile genetic elements including viruses and plasmids. The multiple CRISPR-Cas systems (Types I, II, III) each recognize and target destruction of foreign invader nucleic acids via structurally and functionally div...
ORGANISM(S): Pyrococcus furiosus 
2015-07-10 | E-GEOD-65781 | biostudies-arrayexpress
TranscriptomicsMycobacterial cells have dual nickel-cobalt sensors: sequence-relationships and metal-sites of metal-responsive repressors are not congruent.
A novel ArsR-SmtB family transcriptional repressor, KmtR, has been characterised from mycobacteria. Mutants of M. tuberculosis lacking kmtR show elevated expression of Rv2025c encoding a deduced CDF-family metal-exporter. KmtR-dependent repression of the cdf and kmtR operator-promoters was alleviate...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-17 | E-BUGS-49 | biostudies-arrayexpress
ProteomicsMutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instability
Ribosomal protein mutations are increasingly associated with cancer risk and thought to perturb ribosome function. At the same time, they reportedly activate p53, a critical anti-cancer barrier. To determine how these mutations overcome this protective block to enable tumorigenesis, we generated an ...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-01 | PXD071901 | Pride
Mouse Ribosomal protein mutations Chronic lymphocytic leukemia 
TranscriptomicsGene expression of primary human T Follicular Helper (TFH) cells and naive CD4-positive helper T cells from tonsils of healthy volunteers
In this experiment we generated Affymetrix gene expression data for T Follicular Helper (TFH) cells from tonsils of healthy volunteers (4 biological replicates) and naive CD4-positive helper T cells (2 biological replicates). TFH cells provide a model relevant to SLE as TFH operate upstream of the a...
ORGANISM(S): Homo sapiens 
2019-04-01 | E-MTAB-6637 | biostudies-arrayexpress
TranscriptomicsATAC-seq of primary human T Follicular Helper (TFH) cells and naive CD4-positive helper T cells from tonsils of healthy volunteers
Genome Wide Association Studies (GWAS) have been successful in yielding >60 loci for Systemic Lupus Erythematosus (SLE). However, it is known that GWAS just reports genomic signals and not necessarily the precise localization of culprit genes, with eQTL efforts only able to infer causality to a mino...
ORGANISM(S): Homo sapiens 
2020-05-12 | E-MTAB-6617 | biostudies-arrayexpress
TranscriptomicsPromoter capture-C of primary human T Follicular Helper (TFH) cells and naive CD4-positive helper T cells from tonsils of healthy volunteers
Genome Wide Association Studies (GWAS) have been successful in yielding >60 loci for Systemic Lupus Erythematosus (SLE). However, it is known that GWAS just reports genomic signals and not necessarily the precise localization of culprit genes, with eQTL efforts only able to infer causality to a mino...
ORGANISM(S): Homo sapiens 
2020-05-12 | E-MTAB-6621 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C. difficile following environmental stress
Data is also available from http://bugs.sgul.ac.uk/E-BUGS-55
ORGANISM(S): Clostridium difficile 
2008-11-18 | E-BUGS-55 | biostudies-arrayexpress
UnknownEstimates of the rate of infection and asymptomatic COVID-19 disease in a population sample from SE England.
Not available
S-EPMC7557299 | biostudies-literature
TranscriptomicsTranscription profiling of human carcinoma in situs cells from testis compared to fetal gonocytes, oogonia and cultured embryonic stem cells
Abstract: Testicular cancers in young adult men derive from an inborn precursor lesion, called carcinoma in situ (CIS) of the testis. CIS cells are believed to arise from primordial germ cells or gonocytes that fail to differentiate into the male germ cell lineage, and show a remarkable resemblance ...
ORGANISM(S): Homo sapiens 
2009-06-15 | E-TABM-488 | biostudies-arrayexpress
UnknownEmpagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC10957483 | biostudies-literature
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