Wells Peter A PA

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Yoga and Aerobic Dance for Pain Management in Juvenile Idiopathic Arthritis: Protocol for a Pilot Randomized Controlled Trial.

Not available

S-EPMC7381073 | biostudies-literature

Gene expression profiles of Calu-3 lung epithelial cells after neutrophil transmigration

Injury to the epithelium is integral to the pathogenesis of many inflammatory lung diseases, and epithelial repair is a critical determinant of clinical outcome. However, the signaling pathways regulating such repair are incompletely understood. Herein, we used in vitro and in vivo models to define ...

ORGANISM(S): Homo sapiens

2011-08-27 | E-GEOD-31697 | biostudies-arrayexpress

RNAi profiling by array of human HEp-2 cells with siRNA-mediated depletion of RNase MRP protein components

To identify mRNA substrates for the human RNase MRP complex, we examined the effects of siRNA-mediated depletion of RNase MRP (and RNase P) on the transcriptome of HEp-2 cells. The expression of two RNase MRP protein components, hPop1 and Rpp40, was knocked-down and after 48 hours mRNA was isolated ...

ORGANISM(S): Homo sapiens

2011-04-01 | E-TABM-981 | biostudies-arrayexpress

WB001A: Genome-wide analysis reveals NRP1 as a critical HIF1-E2F7 target gene in the regulation of motor neuron guidance in vivo

In this study, we explored the existence of a transcriptional network co-regulated by E2F7 and HIF1Î±, as we show that expression of E2F7, like HIF1Î±, is induced in hypoxia, and because of the previously reported ability of E2F7 to interact with HIF1Î±. Our genome-wide analysis uncovers a transcrip...

ORGANISM(S): Homo sapiens

2016-01-04 | E-GEOD-66750 | biostudies-arrayexpress

MRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflicts

Rad50 is a component of the conserved MRE11-RAD50-NBS1 (MRN) complex, which functions in genome stability and the cell’s ability to deal with stalled DNA replication forks. We identified Rad50 as a factor important for R-loop tolerance and thus mapped DNA:RNA hybrids in Rad50KO cells and compare the...

ORGANISM(S): Saccharomyces cerevisiae

2019-10-31 | E-MTAB-7885 | biostudies-arrayexpress

3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity.

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S-EPMC10491377 | biostudies-literature

3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility.

Not available

S-EPMC11343244 | biostudies-literature

3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility.

Not available

S-EPMC12683900 | biostudies-literature

Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03).