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TranscriptomicsTranscriptional characterization of Human Lung Organoids (HLOs) using RNAseq
Human lung organoids (HLOs) were derived from human embryonic stem cell line H9 NIH registry #0062. Sequencing of HLOs was performed by the UM DNA Sequencing Core, using Illumina Hi-Seq platform and single-end 50 bp reads. The UM Bioinformatics Core downloaded the reads files from the Sequencing Cor...
ORGANISM(S): Homo sapiens 
2015-03-09 | E-MTAB-3339 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of Calu-3 lung epithelial cells after neutrophil transmigration
Injury to the epithelium is integral to the pathogenesis of many inflammatory lung diseases, and epithelial repair is a critical determinant of clinical outcome. However, the signaling pathways regulating such repair are incompletely understood. Herein, we used in vitro and in vivo models to define ...
ORGANISM(S): Homo sapiens 
2011-08-27 | E-GEOD-31697 | biostudies-arrayexpress
TranscriptomicsPrimary lung fibroblasts treated with hedgehog agonist, purmorphamine
Postnatal tissue quiescence is generally thought to be a default state in the absence of a proliferative stimulus such as injury. We now demonstrate that in the lung, quiescence in the adult is an actively maintained state and is regulated by paracrine hedgehog signaling. Epithelial-specific deletio...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-61026 | biostudies-arrayexpress
ProteomicsProteomic profiling of kidney biopsies in nephrotic syndrome
Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are patterns of kidney injury observed in the filtering units of the kidney known as glomeruli. From the NURTuRE cohort of individuals with nephrotic syndrome (NS), we performed laser microdissection and mass spectrometry ana...
ORGANISM(S): Homo sapiens (Human) 
2024-07-15 | PXD053362 | Pride
Nurture cohort Laser-microdissection Global proteomics Minimal change Focal segmental glomerulosclerosis Nephrotic syndrome 
TranscriptomicsCell host-response to infection with novel human coronavirus EMC predict potential antivirals and important differences with SARS-coronavirus.
Differential expression was determined in Calu-3 cells between mock infected and infection with either Human coronavirus EMC and SARS coronavirus at different times post infection. Calu-3 2B4 cells were infected with Human Coronavirus EMC 2012 (HCoV-EMC) or mock infected. Samples were collected 0, ...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-45042 | biostudies-arrayexpress
UnknownMultiple Dimensions of Environmental Justice and Oil and Gas Development in Pennsylvania.
Not available
S-EPMC10880506 | biostudies-literature
MetabolomicsMetabolic phenotyping of urine from a dementia research cohort
To better understand the molecular mechanisms underpinning physiological variation in human populations, metabolic phenotyping approaches are increasingly being applied to studies involving hundreds and thousands of biofluid samples. Hyphenated ultra-performance liquid chromatography-mass spectromet...
2022-03-01 | MTBLS719 | MetaboLights
TranscriptomicsA Systems Approach to Understanding Human Rhinovirus and Influenza Virus Infection
Human rhinovirus and influenza virus infections of the upper airway lead to colds and the flu and can trigger exacerbations of lower airway diseases including asthma and chronic obstructive pulmonary disease. Despite modest advances in the diagnosis and treatment of infections by these viruses, nove...
ORGANISM(S): Homo sapiens 
2015-12-21 | E-GEOD-71766 | biostudies-arrayexpress
TranscriptomicsPRPF8 CLIP seq for iPSC, kidney organoid, retinal organoid, and retinal epithelium derived from c.6926A>C RPE with Retinitis Pigmentosa patients and CRISPR/Cas9 corrected
Retinitis Pigmentosa is a group of inherited eye disorders characterized by progressive degeneration of photoreceptor cells in the retina, leading to vision loss and eventual blindness. One of the known genetic mutations associated with RP is the c.6926A>C mutation in the RPE (retinal pigment epithe...
ORGANISM(S): Homo sapiens 
2024-03-13 | E-MTAB-13171 | biostudies-arrayexpress
UnknownDexamethasone in Hospitalized Patients with Covid-19.
Not available
S-EPMC7383595 | biostudies-literature
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