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ProteomicsIdentification and characterization of a human MORC2 DNA binding region that is required for gene silencing
The eukaryotic microrchidia (MORC) protein family are DNA gyrase, Hsp90, histidine kinase, MutL (GHKL)-type ATPases involved in gene expression regulation and chromatin compaction. The molecular mechanisms underlying these activities are incompletely understood. Here, we studied the full-length huma...
ORGANISM(S): Homo sapiens (Human) 
2025-05-13 | PXD050648 | Pride
Morc Dna Gene silencing Human 
ProteomicsMolecular insights into THUMPD2-mediated m2G methylation of the U6 snRNA
MMARY THUMPD2 installs N2-methylguanosine (m2G) at position 72 of the U6 snRNA, and this modification, which lies at the catalytic core of the spliceosome, is required for efficient splicing of weak splice sites. However, when during the U6 lifecycle this modification is installed and what features ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD053619 | Pride
Methylation Snrna Crosslinking mass spectrometry Methyltransferase 
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