Sort   by:  
 Page size 
ProteomicsThe oncogenic action of NRF2 depends on de-glycation by Fructosamine-3-kinase (FN3K)
The NRF2 transcription factor controls a cell stress program that is implicated in cancer and there is great interest in targeting NRF2 for therapy. We show that NRF2 activity depends on Fructosamine-3-kinase (FN3K) - a kinase that triggers protein de-glycation. In its absence, NRF2 is extensively g...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-07-08 | PXD014334 | Pride
Hepatocellular carcinoma (hcc) Age Glycation Fn3k Nrf2 
TranscriptomicsFollicular Lymphoma Array CGH
We run aCGH of 64 FL samples and we looked for recurrent chromosomal alterations. we analyzed 64 FL samples by aCGH
ORGANISM(S): Homo sapiens 
2012-09-20 | E-GEOD-40989 | biostudies-arrayexpress
TranscriptomicsGenome-wide RNAi screen identifies miR-19 targets in Notch-induced acute T-cell leukaemia (T-ALL)
MicroRNAs (miRNAs) have emerged as novel cancer genes. In particular, the 17~92 cluster of miRNAs is highly expressed in haematopoietic cancers and promotes lymphomagenesis in vivo1,2. Clinical use of these findings hinges on isolating the oncogenic activity within the 17~92 cluster and defining its...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-20097 | biostudies-arrayexpress
TranscriptomicsRNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer
The translational control of oncoprotein expression is implicated in many cancers. Here we report an eIF4A/DDX2 RNA helicase-dependent mechanism of translational control that contributes to oncogenesis and underlies the anticancer effects of Silvestrol and related compounds. For example, eIF4A promo...
ORGANISM(S): Homo sapiens 
2014-07-27 | E-GEOD-56887 | biostudies-arrayexpress
Sort   by:  
 Page size