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MetabolomicsFructosamine-3-kinase (FN3K) KO in HepG2 liver cancer cells
Not available
ORGANISM(S): Homo sapiens 
ST001375 | MetabolomicsWorkbench
ProteomicsThe oncogenic action of NRF2 depends on de-glycation by Fructosamine-3-kinase (FN3K)
The NRF2 transcription factor controls a cell stress program that is implicated in cancer and there is great interest in targeting NRF2 for therapy. We show that NRF2 activity depends on Fructosamine-3-kinase (FN3K) - a kinase that triggers protein de-glycation. In its absence, NRF2 is extensively g...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-07-08 | PXD014334 | Pride
Hepatocellular carcinoma (hcc) Age Glycation Fn3k Nrf2 
ProteomicsAmiloride reduces FN3K expression to restore sunitinib sensitivity in renal cell carcinoma
The kidney is a vital organ responsible for water and sodium metabolism, while the primary function of amiloride is to promote the excretion of water and sodium. We investigated amiloride enhanced the sunitinib sensitivity in RCC. We found both sunitinib and amiloride displayed cytotoxicity and exer...
ORGANISM(S): Homo Sapiens 
2024-05-07 | PXD052100 |
UnknownStructural basis for FN3K-mediated protein deglycation.
Not available
S-EPMC11455621 | biostudies-literature
UnknownScreening fructosamine-3-kinase (FN3K) inhibitors, a deglycating enzyme of oncogenic Nrf2: Human FN3K homology modelling, docking and molecular dynamics simulations.
Not available
S-EPMC10619859 | biostudies-literature
UnknownFN3K expression in COPD: a potential comorbidity factor for cardiovascular disease.
Not available
S-EPMC7677354 | biostudies-literature
GenomicsThe oncogenic action of NRF2 depends on de-glycation by Fructosamine-3-kinase (FN3K)
The oncogenic action of NRF2 depends on de-glycation by Fructosamine-3-kinase (FN3K)
PRJNA550119 | ENA
UnknownAncestral protein reconstruction reveals the mechanism of substrate specificity in FN3K-mediated deglycation.
Not available
S-EPMC12324494 | biostudies-literature
TranscriptomicsThe oncogenic action of NRF2 depends on de-glycation by Fructosamine-3-kinase (FN3K)
We show that NRF2 activation drives hepatocellular carcinoma development in vivo. Moreover, NRF2 undergoes glucose dependent modification called glycation and requires the de-glycating enzyme FN3K to maintain NRF2' oncogenic functions.
ORGANISM(S): Mus musculus 
2019-06-22 | GSE133160 | GEO
UnknownThe molecular basis of Human FN3K mediated phosphorylation of glycated substrate.
Not available
S-EPMC11326186 | biostudies-literature
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