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ProteomicsElp1_deficency_during_early_myeloid_differentiation
The replacement of microglia with myeloid cells derived from transplanted bone marrow represents a promising cell therapeutic concept for different neurological disorders. Previous studies have primarily been based on freshly harvested grafts, permitting only limited control over cells prior to tran...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-18 | PXD049985 | Pride
Hematopoietic cells Elp1 Mouse Myeloid cells Lc-ms/ms 
TranscriptomicsEarly reprogramming stages and regulators identified by prospective isolation and single cell mass cytometry
In the context of most induced pluripotent stem (iPS) cell reprogramming methods, heterogeneous populations of nonproductive and staggered productive intermediates arise at different reprogramming time points1-11. Despite recent reports claiming substantially increased reprogramming efficiencies us...
ORGANISM(S): Mus musculus 
2015-01-31 | E-GEOD-62957 | biostudies-arrayexpress
TranscriptomicsHierarchical mechanisms for transcription factor-mediated reprogramming of fibroblasts to neurons
Here we reveal a hierarchical mechanism in the direct conversion of fibroblasts into induced neuronal (iN) cells mediated by the transcription factors Ascl1, Brn2, and Myt1l. Examination of global transcriptional changes and mapping genome-wide transcription factors occupancy at distinct time points...
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-43916 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of mouse polycomb group (PcG) proteins in embryonic stem cells
Polycomb group (PcG) proteins are highly conserved from flies to mammals and many of these factors have essential roles in early embryonic development. PcG proteins comprise two multimeric complexes, the Polycomb Repressive complexes 1 and 2 (PRC1 and 2), which have been shown to repress transcript...
ORGANISM(S): Mus musculus 
2006-05-09 | E-WMIT-12 | biostudies-arrayexpress
GenomicsLocalization of the Rb tumor suppressor in MEFs during reprogramming to iPS and the consequence of Rb loss on the transcriptional profile and histone landscape in these cells
The reprogramming of differentiated cells to an embryonic stem cell-like state provides a powerful system to explore fundamental mechanisms of development, including how mammalian cells establish and maintain pluripotency and long-term self-renewal capability. Based on the similarities between embry...
ORGANISM(S): Mus musculus 
2014-11-13 | E-GEOD-40594 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ES cells, neural precursor cells and embryonic fibroblasts
Expression profiles for isogenic (129SvJae x C57BL/6) murine embryonic stem (ES) cells, neural precursors (NPC) obtained through in vitro differentiation of the ES cells, and embryonic fibroblasts (MEF) obtained at day 13.5. Experiment Overall Design: 3 replicates of wt ES cells, 3 replicates of wt...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-8024 | biostudies-arrayexpress
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