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ProteomicsEndogenous androgen receptor proteomic profiling reveals genomic subcomplex involved in prostate tumorigenesis
Androgen receptor (AR) is a key player in prostate cancer development and progression. Here we applied immunoprecipitation mass spectrometry of endogenous AR in LNCaP cells to identify components of the AR transcriptional complex. In total, 66 known and novel AR interactors were identified in the pr...
ORGANISM(S): Homo sapiens (Human) 
2017-10-27 | PXD008056 | Pride
Prostate cancer Interactome Rime Proteomics Androgen receptor 
GenomicsChIP-Seq for RIP140, using the human breast cancer cell line MCF-7 in the absence of hormone or after treatment with Estradiol
This experiment is designed to assess the role of RIP140 in estrogen receptor-dependent gene expression in MCF7 luminal breast cancer cells. Hormone deprived MCF7 cells were treated for 3 hours with E2 or DMSO control, after which samples were processed for ChIp-seq for RIp140.
ORGANISM(S): Homo sapiens 
2015-03-16 | E-MTAB-2576 | biostudies-arrayexpress
TranscriptomicssiRIP140 and gene expression effects in E2-treated MCF7 cells
This experiment is designed to assess the role of RIP140 in estrogen receptor-dependent gene expression in MCF7 luminal breast cancer cells. MCF7 cells were transfected with an siRNA to target RIP140 or siControl, and subsequently depleted from hormones for three days. Thereafter, cells were treated...
ORGANISM(S): Homo sapiens 
2015-03-17 | E-MTAB-2577 | biostudies-arrayexpress
UnknownThe Cancer SENESCopedia: A delineation of cancer cell senescence.
Not available
S-EPMC8333195 | biostudies-literature
UnknownEvaluation of the HER/PI3K/AKT Family Signaling Network as a Predictive Biomarker of Pathologic Complete Response for Patients With Breast Cancer Treated With Neratinib in the I-SPY 2 TRIAL.
Not available
S-EPMC7446527 | biostudies-literature
ProteomicsPhosphoproteomics of truncated FGFR2, a clinically actionable oncogene in multiple cancers
Somatic hotspot mutations and structural amplifications and fusions affecting fibroblast growth factor receptor 2 (FGFR2) occur in multiple cancer types. However, clinical responses to FGFR inhibitors (FGFRi) have remained variable, emphasizing a need to better understand which FGFR2 alterations are...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-06 | PXD031711 | Pride
Cancer Fgfr2 Imac Mouse model Ptyrip Label-free Phosphoproteomics 
UnknownFanconi anemia and homologous recombination gene variants are associated with functional DNA repair defects in vitro and poor outcome in patients with advanced head and neck squamous cell carcinoma.
Not available
S-EPMC5915066 | biostudies-literature
UnknownComparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer.
Not available
S-EPMC6344487 | biostudies-literature
UnknownCodon-specific KRAS mutations predict survival benefit of trifluridine/tipiracil in metastatic colorectal cancer.
Not available
S-EPMC10033412 | biostudies-literature
UnknownA living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression.
Not available
S-EPMC10171335 | biostudies-literature
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