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ProteomicsPhosphoproteomics of truncated FGFR2, a clinically actionable oncogene in multiple cancers
Somatic hotspot mutations and structural amplifications and fusions affecting fibroblast growth factor receptor 2 (FGFR2) occur in multiple cancer types. However, clinical responses to FGFR inhibitors (FGFRi) have remained variable, emphasizing a need to better understand which FGFR2 alterations are...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-06 | PXD031711 | Pride
Cancer Fgfr2 Imac Mouse model Ptyrip Label-free Phosphoproteomics 
ProteomicsIntact mass spectrometry analysis of covalent binding between purified recombinant human FGFR2 V564F protein and small-molecule compound LC-F2-1 incubated at a molar ratio of 1:2 or 1:5 at room temperature via Agilent 6230 time-of-flight LC/MS system for the characterization of their covalent binding products in protein-drug interaction studies
This dataset corresponds to an intact mass spectrometry study focusing on the covalent binding interaction between purified FGFR2 V564F protein and compound LC-F2-1. The purified FGFR2 V564F was adjusted to 28 μM, then incubated with LC-F2-1 at molar ratios of 1:2 or 1:5 for 4 hours at room temperat...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD073416 | Pride
Covalent binding Lc-ms Lc-f2-1 Fgfr2 v564f 
GenomicsMassive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (iCCA) is a fatal bile duct cancer with dismal prognosis and limited therapeutic options. By performing RNA- and exome sequencing analyses we have discovered a novel fusion event, FGFR2-PPHLN1 (16%), and damaging mutations in the ARAF oncogene (11%). Methods: mRNA and...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-63420 | biostudies-arrayexpress
ProteomicsThe C-terminal phenylalanine–serine KDBS motif prevents constitutive activation of the FGFR2 proto-oncogene
Dysregulated FGF/FGFR signaling leads to a variety of pathologies. These include cancer as well as congenital syndromes that affect skeleton development, impair the response to injury, and/or result in metabolic disorders. In human cancers, the FGFR genes can be affected by hotspot missense mutation...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-17 | PXD041797 | Pride
Fgfr2 signaling Immunoprecipitation Shotgun Lc-ms/ms 
GenomicsFGFR2 C-terminal truncation in cancer
FGFR2 C-terminal truncation in cancer
PRJEB42514 | ENA
GenomicsSignaling suppressive determinants of the FGFR2 C-terminus
Signaling suppressive determinants of the FGFR2 C-terminus
PRJEB60417 | ENA
TranscriptomicsFGFR2 Signaling Underlies p63 Oncogenic Function in Squamous Cell Carcinoma
This study was designed to examine the requirement for the p63 transcription factor in Squamous Cell Carcinoma (SCC) tumor maintenance in an in vivo murine system. A tamoxifen-inducible Keratin 14-driven Cre recombinase transgene was used to conditionally excise p63 in advanced murine SCC tumors. ...
ORGANISM(S): Mus musculus 
2013-08-06 | E-GEOD-45929 | biostudies-arrayexpress
ProteomicsDifferential responses to kinase inhibition in FGFR2-addicted triple negative breast cancer cells: a quantitative phosphoproteomics study
Fibroblast Growth Factor (FGF) dependent signalling is frequently activated in cancer by a variety of different mechanisms. However, the downstream signal transduction pathways involved are poorly characterised. Here a quantitative differential phosphoproteomics approach, SILAC, is applied to identi...
ORGANISM(S): Homo sapiens (Human) 
2020-05-20 | PXD016777 | Pride
Su5402 Fgf Silac Phosphorylation Mapk Mtor 
GenomicsIdentification of potent biparatopic antibodies targeting FGFR2 fusion driven cholangiocarcinoma
Identification of potent biparatopic antibodies targeting FGFR2 fusion driven cholangiocarcinoma
PRJNA1186575 | ENA
TranscriptomicsActivation of FGFR2-kinase domain (iF2 construct)
Genome-wide association studies for breast cancer have identified over 80 different risk regions in the genome, with the FGFR2 locus consistently identified as the most strongly associated locus. However, we know little about the mechanisms by which the FGFR2 locus mediates risk or the pathways in w...
ORGANISM(S): Homo sapiens 
2013-07-17 | E-GEOD-48925 | biostudies-arrayexpress
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