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TranscriptomicsIdentification of genes critical for resistance to infection by West Nile virus using RNA-Seq analysis
Background: West Nile virus is an emerging infection of biodefense concern and there are no available treatments or vaccines. Here we used a high-throughput method based on a novel gene expression analysis, RNA-Seq, to give a global picture of differential gene expression by primary human macrophage...
ORGANISM(S): Homo sapiens 
2014-01-08 | E-GEOD-40718 | biostudies-arrayexpress
MetabolomicsA Cross-Platform Metabolomics Comparison Identifies Serum Metabolite Signatures of Liver Fibrosis Progression in Chronic Hepatitis C Patients
Metabolomics offers new insights into disease mechanisms that is enhanced when adopting orthogonal instrumental platforms to expand metabolome coverage, while also reducing false discoveries by independent replication. Herein, we report the first inter-method comparison when using multisegment injec...
2023-08-22 | MTBLS3111 | MetaboLights
ProteomicsComparison of the Human Neuronal Proteome upon Japanese Encephalitis or West Nile Virus Infection and potential role of mosquito saliva in neuropathogenesis
Neurotropic flavivirus Japanese encephalitis virus (JEV) and West Nile virus (WNV) are amongst the leading causes of encephalitis. Using label-free quantitative proteomics, we identified proteins differentially expressed upon JEV (gp-3, RP9) or WNV (IS98) infection of human neuroblastoma cells. Both...
ORGANISM(S): West Nile virus Culex pipiens pipiens Homo sapiens (Human) Japanese encephalitis virus 
2020-05-14 | PXD016805 | Pride
Mosquito Label free Japanese encephalitis West nile 
ProteomicsQuantitative proteomic analysis of bronchoalveolar lavage fluid in West Highland white terriers with canine idiopathic pulmonary fibrosis C4PR_LIV
Canine idiopathic pulmonary fibrosis (CIPF) is a chronic, progressive, interstitial fibrosing lung disease, manifesting as cough, exercise intolerance and ultimately, dyspnea and respiratory failure. It mainly affects West Highland white terriers (WHWTs), lacks curable treatment and has a poor progn...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2022-05-20 | PXD028916 | Pride
Bronchoalveolar lavage fluid  canine  reflux aspiration  proteomics: west highland white terrier 
ProteomicsProteasome dysfunction leads to enhanced autophagy mediated degradation of mutant lamin A/C
Lamin A/C are nuclear intermediate filament proteins that form a proteinaceous meshwork called lamina beneath the inner nuclear membrane. Mutations in the LMNA gene encoding lamin A/C cause a heterogenous group of inherited degenerative diseases known as laminopathies. Previous studies have revealed...
ORGANISM(S): Homo sapiens (Human) 
2022-09-07 | PXD033937 | Pride
Lamin a/c Autophagy Ubiquitin-proteasome-system Disease mutations Degradation Ubiquitin 
TranscriptomicsInteractions of wheat aleurine and plant omega-3 fatty acids on the rat gut microbiota
Microbiota from rats fed with wheat aleurone and plant omega fatty acids In this study we investigated how an AX-rich WA and ALA from linseed oil (LO) modulate the gut microbiota of rats. Wistar rats were fed a standard diet and received either an iso-energetic control oil (PO), control oil + aleuro...
ORGANISM(S): Rattus norvegicus 
2013-05-02 | E-GEOD-46557 | biostudies-arrayexpress
TranscriptomicsDifferentially activated CD8 T cells in liver and gut
NaM-CM-/ve, liver- and gut-activated CD8 OT-I T cells show differential migration behaviour. To analyze which genes could be responsible for different migration patterns, naM-CM-/ve, liver-activated and gut-activated CD8 T cells were isolated and compared for their gene expression profile. Gene expr...
ORGANISM(S): Mus musculus 
2014-02-25 | E-GEOD-39449 | biostudies-arrayexpress
UnknownA novel lead compound CM-118: antitumor activity and new insight into the molecular mechanism and combination therapy strategy in c-Met- and ALK-dependent cancers.
Not available
S-EPMC4049788 | biostudies-literature
UnknownThe effect of pericolic lymph nodes metastasis beyond 10 cm proximal to the tumor on patients with rectal cancer.
Not available
S-EPMC7304140 | biostudies-literature
ProteomicsIdentification of phosphorylation sites of BAG3
HEK293 cells were cultured in two 10-cm dishes and transfected with BAG3-FLAG as well as Myc vector, CaMKIIβ(D-S)-Myc, and CaMKIIδ(D-S)-MYC, respectively. After the cells were transfected for 24 h, they were treated with the indicated regent. The cells were lysed with NP-40 alternative cell lysis bu...
ORGANISM(S): Homo sapiens (Human) 
2024-08-20 | PXD054722 | Pride
Phosphorylation sites Bag3 Human 
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