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Wilson disease (WD) is a severe metabolic disorder caused by genetic inactivation of copper-transporting ATPase ATP7B. In WD, copper accumulates in several tissues, particularly in the liver, inducing marked time-dependent pathological changes. To identify initial events in the copper-dependent de...
ORGANISM(S): Mus musculus 
During inflammation immune cells can induce endothelial activation and angiogenesis by cytokines and other mediators1,2. The inhibition of inflammation-associated angiogenesis ameliorates inflammatory diseases by reducing the recruitment of tissue infiltrating leukocytes3-5. However, there is limite...
ORGANISM(S): Mus musculus (Mouse) 
2017-01-31 | PXD004606 | Pride
High intake of orange juice and cola differently affects metabolic risk in healthy subjects while fecal microbiota remains unchanged
Transcription profiling of third instar male larvae of two different heteroallelic combinations of ssdp hypomorphic alleles, ssdp[neo48]/ssdp]BG1663] and ssdp[31]/ssdp[BG1663] were compared to each of the corresponding single heterozygotes 22 hybridizations were conducted, these include biological r...
ORGANISM(S): Drosophila melanogaster 
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