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TranscriptomicsCold hardening gene expression
Cold hardening treatment, a brief exposure to low temperatures (e.g. 0°C for 2 h), can protect certain insects against subsequent exposure to temperatures sufficiently low to cause damage or lethality. Microarray analysis to examine the changes in transcript abundance associated with cold hardening ...
ORGANISM(S): Drosophila melanogaster 
2005-11-30 | E-GEOD-2989 | biostudies-arrayexpress
TranscriptomicsSMAUG is required for zygotic transcription during the maternal-zygotic transition MZT
Microarray analysis of zygotic gene expression in 2-to-3 hour wild-type (wt) and smg mutant embryos. Expression is relative to mature, stage 14 oocytes, which contain the full maternal pool of mRNA. Strictly maternal genes that are not transcribed at the MZT contribute approximately 80% of transc...
ORGANISM(S): Drosophila melanogaster 
2010-06-19 | E-GEOD-13287 | biostudies-arrayexpress
TranscriptomicsThermoprotection in the Drosophila hsf4 mutant
In Drosophila larvae, acquired synaptic thermotolerance following heat shock has previously been shown to correlate with the induction of heat shock proteins (Hsps) including HSP70. We tested the hypothesis that synaptic thermotolerance would be significantly diminished in a temperature-sensitive st...
ORGANISM(S): Drosophila melanogaster 
2005-11-30 | E-GEOD-2998 | biostudies-arrayexpress
TranscriptomicsmiR-309-dependent unstable maternal mRNAs are stabilized in smaug mutants
The behavior of 410 miR-309-dependent maternal mRNAs (from Bushati et al., 2008) in embryos from wild type and smg-mutant females relative to wild-type stage 14 oocyte reference RNA. All are unstable in wild-type while almost 85% are stabilized in smg mutants mRNA was extracted from staged embryos a...
ORGANISM(S): Drosophila melanogaster 
2010-06-19 | E-GEOD-13288 | biostudies-arrayexpress
TranscriptomicsSMAUG Is a Major Regulator of Maternal mRNA Destabilization in Drosophila
In animals, egg activation triggers a cascade of posttranscriptional events that act on maternally synthesized RNAs. We show that, in Drosophila, the PAN GU (PNG) kinase sits near the top of this cascade, triggering translation of SMAUG (SMG), a multifunctional posttranscriptional regulator conserve...
ORGANISM(S): Drosophila melanogaster 
2007-09-13 | E-GEOD-8910 | biostudies-arrayexpress
MetabolomicsMetabolic phenotyping of urine from a dementia research cohort
To better understand the molecular mechanisms underpinning physiological variation in human populations, metabolic phenotyping approaches are increasingly being applied to studies involving hundreds and thousands of biofluid samples. Hyphenated ultra-performance liquid chromatography-mass spectromet...
2022-03-01 | MTBLS719 | MetaboLights
UnknownEarly surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial.
Not available
S-EPMC4821633 | biostudies-literature
UnknownBehavior therapy for children with Tourette disorder: a randomized controlled trial.
Not available
S-EPMC2993317 | biostudies-literature
ProteomicsDiscovery of a Small Molecule Secreted Clustering Enhancer that Improves Memory in Alzheimer's Disease Mice
Here, we present findings from a drug discovery program aimed at developing small molecules that enhance brain sCLU levels and assessed their impact on AD pathology and cognition. A high-throughput screening campaign identified two classes of epigenetic modulators to increase sCLU levels, and medici...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-30 | PXD060171 | Pride
Alzheimers disease Epigenetic modulator Memory improvement Secreted clustering enhancer 
ProteomicsDiscovery of a Small Molecule Secreted Clustering Enhancer that Improves Moemory in Alzheimer's Disease Mice
Here, we present findings from our drug discovery program to identify small molecules that enhance sCLU levels and assess their impact on AD pathology and cognition in a murine model of AD. A high-throughput screening campaign identified two classes of epigenetic modulators that increase sCLU levels...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-30 | PXD060173 | Pride
Epigenetic modulator Alzheimer's disease Memory improvement Secreted clustering enhancer 
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