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TranscriptomicsTranscription profiling of nude mice tumor biopsies generated by the injection of mesenchymal stem cells (MSC)
Transformed MSC were injected subcutaneously into the flank of athymic CD1 nude mice (C/River). Biopsies of 1.5 cm spindle cell tumours were taken.
ORGANISM(S): Homo sapiens 
2006-12-26 | E-MEXP-562 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of the astrocyte transcriptome in the ageing brain: relationship to Alzheimer's pathology and ApoE genotype
Astrocyte dysfunction impacts their normal function, including neuronal support, thereby contributing to neurodegenerative pathologies including Alzheimer's disease (AD). Therefore to understand the role of astrocytes in the pathogenesis of age-related disorders we analysed the gene expression profi...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-29652 | biostudies-arrayexpress
TranscriptomicsA small molecule modulator of prion protein enhances proliferation and engraftment of mesenchymal stem cells and extends their lifespan upon serial passage in culture
Human mesenchymal stem cells (hMSC) play an important role in the maintenance of bone and blood. Most protocols rely on their in vitro expansion prior to clinical use. However, several groups including our own have shown that hMSC lose proliferation and differentiation ability with serial passage in...
ORGANISM(S): Homo sapiens 
2012-01-30 | E-GEOD-31205 | biostudies-arrayexpress
TranscriptomicsSingle cell differences in matrix gene expression do not predict matrix deposition
We performed RNA sequencing on several clones of bovine mesenchymal stem cells from the same donor. Bulk mRNA sequencing in 17 different clones from the same donor and a heterogeneous population from the same donor.
ORGANISM(S): Bos taurus 
2016-01-18 | E-GEOD-76881 | biostudies-arrayexpress
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