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ProteomicsThe response regulator MtrA controls development through activation of bldM and whiI in Streptomyces venezuelae
The response regulator MtrA is highly conserved in Streptomyces species where it coordinates antibiotic production with sporulation. Loss of MtrA results in a conditional bald phenotype in S. avermitilis, S. coelicolor and S. venezuelae, where the production of aerial hyphae and spores is blocked on...
ORGANISM(S): Streptomyces venezuelae 
2026-05-21 | PXD069151 | Pride
Mtra Bldm Streptomyces Sporulation Whii Response regulators 
TranscriptomicsTranscription profiling of the wild type and the deletion mutants of the bldM and whiI developmental genes of Streptomyces venezuelae ATCC 10712 at 7 time points from 8 to 20 hours of growth
BldM and WhiI are both orphan, atypical response regulators found in Streptomyces species. They have complex developmental roles in aerial mycelium formation and sporulation in these bacteria. The aim of this transcription profiling experiment was to see how the deletion of these genes affects genom...
ORGANISM(S): Streptomyces venezuelae 
2015-07-01 | E-MTAB-2716 | biostudies-arrayexpress
GenomicsSvenBldMWhiIChIPSeq
To determine the influence of BldM and WhiI on the binding of each other to their respective binding sites in the genome of Streptomyces venezuelae, ChIP-Seq experiments were carried out using polyclonal antibodies against the wild type proteins as well as anti-FLAG antibodies against FLAG-tagged pr...
ORGANISM(S): Streptomyces venezuelae 
2015-05-19 | E-MTAB-2698 | biostudies-arrayexpress
UnknownResponse regulator heterodimer formation controls a key stage in Streptomyces development.
Not available
S-EPMC4125116 | biostudies-literature
UnknownAn unusual response regulator influences sporulation at early and late stages in Streptomyces coelicolor.
Not available
S-EPMC1855786 | biostudies-literature
UnknownInfluence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies.
Not available
S-EPMC3612774 | biostudies-literature
GenomicsSvenBldMWhiIChIPSeq
SvenBldMWhiIChIPSeq
PRJEB6649 | ENA
UnknownMultimodal brain-age prediction and cardiovascular risk: The Whitehall II MRI sub-study.
Not available
S-EPMC8121758 | biostudies-literature
GenomicsStreptomyces coelicolor A3(2) strain M600 wild type transcriptome ChIP-chip with the bldC null mutant
Global regulation by the Streptomyces coelicolor atypical MerR-like transcription factor BldC. BldC is a transcriptional regulator essential for morphological development and antibiotic production in Streptomyces coelicolor. Here we identify the BldC regulon by means of chromatin immunoprecipitation...
ORGANISM(S): Streptomyces coelicolor Streptomyces coelicolor A3(2) 
2013-01-01 | GSE28908 | GEO
UnknownRefinement of variant selection for the LDL cholesterol genetic risk score in the diagnosis of the polygenic form of clinical familial hypercholesterolemia and replication in samples from 6 countries.
Not available
S-EPMC4892342 | biostudies-literature
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