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ProteomicsThe response regulator MtrA controls development through activation of bldM and whiI in Streptomyces venezuelae
The response regulator MtrA is highly conserved in Streptomyces species where it coordinates antibiotic production with sporulation. Loss of MtrA results in a conditional bald phenotype in S. avermitilis, S. coelicolor and S. venezuelae, where the production of aerial hyphae and spores is blocked on...
ORGANISM(S): Streptomyces venezuelae 
2026-05-21 | PXD069151 | Pride
Mtra Bldm Streptomyces Sporulation Whii Response regulators 
GenomicsMtrA regulation of essential peptidoglycan cleavage in Mycobacterium tuberculosis during infection [mtrA_knockdown]
MtrA regulation of essential peptidoglycan cleavage in Mycobacterium tuberculosis during infection [mtrA_knockdown]
PRJNA702058 | ENA
UnknownMycobacterium tuberculosis oriC sequestration by MtrA response regulator.
Not available
S-EPMC4700885 | biostudies-literature
GenomicsMtrA regulation of essential peptidoglycan cleavage in Mycobacterium tuberculosis during infection [MtrA_OE_pH]
MtrA regulation of essential peptidoglycan cleavage in Mycobacterium tuberculosis during infection [MtrA_OE_pH]
PRJNA702057 | ENA
GenomicsDeletion of MtrA inhibits cellular development of Streptomyces coelicolor and alters expression of developmental regulatory genes
Deletion of MtrA inhibits cellular development of Streptomyces coelicolor and alters expression of developmental regulatory genes
PRJNA412198 | ENA
TranscriptomicsDeletion of MtrA inhibits cellular development of Streptomyces coelicolor and alters expression of developmental regulatory genes
The developmental life cycle of Streptomyces species includes aerial hyphae formation and spore maturation, two distinct developmental processes that are controlled, respectively, by two families of developmental regulatory genes, bld and whi. In this study, we show that the response regulator MtrA ...
ORGANISM(S): Streptomyces coelicolor 
2017-09-27 | GSE104263 | GEO
TranscriptomicsMtrA regulation of essential peptidoglycan cleavage in Mycobacterium tuberculosis during infection [mtrA_knockdown]
The success of Mycobacterium tuberculosis (Mtb) is largely due to its ability to withstand numerous stresses imposed by host immunity. Here, we present a data-driven model that captures these adaptive mechanisms and reveals the dynamic interplay of host-derived stresses and genome-encoded regulatory...
ORGANISM(S): Mycolicibacterium smegmatis Mycobacterium tuberculosis 
2021-07-16 | GSE166805 | GEO
TranscriptomicsMtrA regulation of essential peptidoglycan cleavage in Mycobacterium tuberculosis during infection [MtrA_OE_pH]
The success of Mycobacterium tuberculosis (Mtb) is largely due to its ability to withstand numerous stresses imposed by host immunity. Here, we present a data-driven model that captures these adaptive mechanisms and reveals the dynamic interplay of host-derived stresses and genome-encoded regulatory...
ORGANISM(S): Mycobacterium tuberculosis 
2021-07-16 | GSE166804 | GEO
GenomicsChIP-Seq data of the Streptomyces venezualae protein Sven2756 (MtrA) over a time course of 10h, 12h, 14h, 16h, 18h and 20h.
We report the results of ChIP-Seq experiment investigating the MtrA TCS response regulator. The experiment utilised an in trans copy of mtrA with an N-terminal 3xFlag tag encoded on the plasmid pMS82 (containing a phiBT1 integration site). The experiment utilised beads associated with anti-flag anti...
ORGANISM(S): Streptomyces venezuelae ATCC 10712 
2017-07-12 | GSE84311 | GEO
UnknownMtrA of the sodium ion pumping methyltransferase binds cobalamin in a unique mode.
Not available
S-EPMC4915002 | biostudies-literature
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