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UnknownGPR55 ligands promote receptor coupling to multiple signalling pathways.

Background and purpose

Although GPR55 is potently activated by the endogenous lysophospholipid, L-alpha-lysophosphatidylinositol (LPI), it is also thought to be sensitive to a number of cannabinoid ligands, including the prototypic CB1 receptor antagonists AM251 and SR141716A (Rimonabant). I...
S-EPMC2931561 | biostudies-literature
UnknownGut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic morphine.
The therapeutic benefits of opioids are compromised by the development of analgesic tolerance, which necessitates higher dosing for pain management thereby increasing the liability for drug dependence and addiction. Rodent models indicate opposing roles of the gut microbiota in tolerance: morphine-i...
S-EPMC11042308 | biostudies-literature
UnknownThe GPCR-associated sorting protein 1 regulates ligand-induced down-regulation of GPR55.

Background and purpose

Many GPCRs, including the CB(1) cannabinoid receptor, are down-regulated following prolonged agonist exposure by interacting with the GPCR-associated sorting protein-1 (GASP-1). The CB(1) receptor antagonist rimonabant has also recently been described to be an agonist ...
S-EPMC3366063 | biostudies-literature
UnknownReduced lung-cancer mortality with low-dose computed tomographic screening.

Background

The aggressive and heterogeneous nature of lung cancer has thwarted efforts to reduce mortality from this cancer through the use of screening. The advent of low-dose helical computed tomography (CT) altered the landscape of lung-cancer screening, with studies indicating that low-d...
S-EPMC4356534 | biostudies-literature
UnknownResults of the two incidence screenings in the National Lung Screening Trial.

Background

The National Lung Screening Trial was conducted to determine whether three annual screenings (rounds T0, T1, and T2) with low-dose helical computed tomography (CT), as compared with chest radiography, could reduce mortality from lung cancer. We present detailed findings from the f...
S-EPMC4307922 | biostudies-literature
UnknownThe National Lung Screening Trial: overview and study design.
The National Lung Screening Trial (NLST) is a randomized multicenter study comparing low-dose helical computed tomography (CT) with chest radiography in the screening of older current and former heavy smokers for early detection of lung cancer, which is the leading cause of cancer-related death in t...
S-EPMC3009383 | biostudies-literature
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