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GenomicsAP-1 family members act at DNA targets in conjunction with Sox9 to promote chondrocyte hypertrophy
A comprehensive analysis of Sox9 binding profiles in developing chondrocytes identified marked enrichment of an AP-1-like motif (Ohba et al. 2015). Here, we have explored the functional interplay between Sox9 and AP-1 in mammalian chondrocyte development. Among AP-1 family members, Jun and Fosl2 wer...
ORGANISM(S): Mus musculus 
2016-02-29 | E-GEOD-73372 | biostudies-arrayexpress
TranscriptomicsEthylene and 1-MCP differentially regulate gene expression during onion (Allium cepa L.) sprout suppression
Onion is regarded as non-climacteric. In onion, ethylene can suppress sprouting however, the ethylene binding inhibitor, 1-MCP can also suppress sprout growth although it is unknown how ethylene and 1-MCP elicit the same response. In this study, onion bulbs were treated with 10 μL L-1 ethylene or 1...
ORGANISM(S): Allium cepa 
2011-06-29 | E-GEOD-27132 | biostudies-arrayexpress
TranscriptomicsSub-chronic forestomach transcriptional response in adult male MutaTMMouse following oral exposure to benzo(a)pyrene
Benzo(a)pyrene is a well-established human carcinogen in humans and rodents. In the present study, we sought to determine the dose- and time-dependent changes in gene expression upon oral exposure to benzo(a)pyrene. Adult male MutaTMMouse were exposed to three doses of benzo(a)pyrene or vehicle cont...
ORGANISM(S): Mus musculus 
2013-09-27 | E-GEOD-43438 | biostudies-arrayexpress
TranscriptomicsPulmonary gene expression in MutaTMMouse orally gavaged with three doses of benzo(a)pyrene and vehicle control
In this study, we investigate mRNA profiles in lung of mice exposed to benzo(a)pyrene. Male mice were exposed to three doses (25, 50, and 75 mg/kg/day BaP) for 28 days and profiles were examined three days post-exposure. Our analyses reveal that BaP causes pulmonary specific cellular transformation ...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-35718 | biostudies-arrayexpress
GenomicsNHLBI and NIDDK Sponsored GWAS in Benign Ethnic Neutropenia/Leukopenia (BEN) in African-Americans (age >45 yrs old) from the REGARDS

Benign ethnic neutropenia (BEN) is a clinical condition more commonly observed in African-Americans. It is characterized by a relative reduction in neutrophil count by about 1000 cells per microliter, leading to a decrease in total leukocyte count by similar decrement. Previous reports of this co...

phs000507.v1.p1 | EGA
TranscriptomicsTranscription profiling of human lymphatic endothelial cells, mouse dermal cells and human skin cells reveals an inflammation-induced mechanism for leukocyte transmigration of lymphatic vessel endothelium.
The exit of antigen-presenting cells (APC) and lymphocytes from inflamed skin to afferent lymph is vital for the initiation and maintenance of dermal immune responses. How such exit is achieved and how cells transmigrate the distinct endothelium of lymphatic vessels is however unknown. Here we show ...
ORGANISM(S): Homo sapiens 
2008-11-07 | E-GEOD-6257 | biostudies-arrayexpress
TranscriptomicsLack of hepatic response of microRNA in mice following chronic benzo(a)pyrene exposure (miRNA)
Benzo[a]pyrene (BaP) is a very extensively studied prototypical polycyclic aromatic hydrocarbons (PAHs). Previous work in our laboratory showed no changes of microRNA (miRNA) expression in liver following a 3 days exposure to BaP, suggesting a lack of miRNA transcriptional responses to aryl hydrocar...
ORGANISM(S): Mus musculus 
2011-10-18 | E-GEOD-24909 | biostudies-arrayexpress
TranscriptomicsInterlaboratory study to determine the reproducibility of toxicogenomics datasets
The application of toxicogenomics as a predictive tool for chemical risk assessment has been under evaluation by the toxicology community for more than a decade. However, toxicogenomics predominately remains a tool for investigative research rather than for regulatory risk assessment. In this study,...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-25936 | biostudies-arrayexpress
TranscriptomicsThe DNA damage response transcriptome of the moss Physcomitrella patens
The moss Physcomitrella patens is remarkable for the ease with which mutant alleles of any gene can be generated by highly efficient homologous recombination-mediated gene targeting. Targeted transgene integration is believed to be mediated through the capture of transforming DNA by the homologous r...
ORGANISM(S): Physcomitrella patens 
2010-11-10 | E-GEOD-25237 | biostudies-arrayexpress
TranscriptomicsLack of hepatic response of microRNA in mice following chronic benzo(a)pyrene exposure (gene expression)
Benzo[a]pyrene (BaP) is a very extensively studied prototypical polycyclic aromatic hydrocarbons (PAHs). Previous work in our laboratory showed no changes of microRNA (miRNA) expression in liver following a 3 days exposure to BaP, suggesting a lack of miRNA transcriptional responses to aryl hydrocar...
ORGANISM(S): Mus musculus 
2011-10-18 | E-GEOD-24907 | biostudies-arrayexpress
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