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ProteomicsA covalent fragment screen identifies ferroptosis induced by GPX4 inhibition as a vulnerability of senescent cells
Senescent cells drive ageing and age-related pathologies, including cancer. Consequently, senolytics, drugs that selectively kill senescent cells, have a broad therapeutic appeal. Here, we report a senolytic screen of a library of 10,480 covalent fragments. Amongst 38 identified hits, we found a sub...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD068417 | Pride
Gpx4 Rsl3 Cancer Senescence Chloroacetamides Covalent fragments Ferroptosis Senolytics One-two punch Covalent inhibitors 
ProteomicsOxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics
Protein glycosylation, a complex and heterogeneous post-translational modification that is frequently dysregulated in disease, has been difficult to analyse at scale. Here we report a data-independent acquisition technique for the large-scale mass-spectrometric quantification of glycopeptides in pla...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-29 | MSV000089567 | MassIVE
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