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ProteomicsMulti-omics of a pre-clinical model of diabetic cardiomyopathy reveals increased fatty acid supply impacts mitochondrial metabolic selectivity
The incidence of type 2 diabetes (T2D) is increasing globally, with long-term implications for human health and longevity. Heart disease is the leading cause of death in T2D patients, who display an elevated risk of an acute cardiovascular event and worse outcomes following such an insult. The under...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-11-01 | PXD029587 | Pride
Heart Proteomics Multiomics Diabetic cardiomyopathy 
ProteomicsTherapeutic inhibition of acid sensing ion channel 1a recovers heart function after ischemia-reperfusion injury
Background: Ischemia-reperfusion injury (IRI) is one of the major risk factors implicated in morbidity and mortality associated with cardiovascular disease. During cardiac ischemia, the build-up of acidic metabolites results in decreased intracellular and extracellular pH that can reach as low as 6....
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2022-11-01 | PXD024581 | Pride
Heart Venom Mass spectrometry Therapeutic Human induced pluripotent stem cells Ischemia-reperfusion injury 
ProteomicsInterferon stimulated changes in the brain phosphoproteome
Type I interferons (IFN-Is) are immunoregulatory cytokines that are essential for normal host antiviral responses. The current understanding is that IFN-Is mediate their effects through the expression of several hundred interferon-regulated genes. Here we identified a novel IFN-I response mechanism ...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD014443 | Pride
Astrocytes Brain Mouse Interferon Microglia Phosphoproteomics Lc-ms/ms 
TranscriptomicsFormaldehyde-induced changes in microRNA signaling [Affymetrix]
In addition to gaining knowledge on in vivo miRNA responses to formaldehyde, we set out to relate these miRNA responses to transcriptional profiles modified by formaldehyde. Rats were exposed by inhalation to either 0 or 2 ppm formaldehyde (6 hours/day) for 28 days. Genome-wide transcriptional profi...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-42394 | biostudies-arrayexpress
TranscriptomicsFormaldehyde-induced changes in microRNA signaling [Agilent]
MicroRNAs (miRNAs) are critical regulators of gene expression, yet much remains unknown regarding miRNA changes resulting from environmental exposures and whether they influence pathway signaling across various tissues and time. To gain knowledge on these novel topics, we set out to investigate in v...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-42393 | biostudies-arrayexpress
Unknown12q24 locus association with type 1 diabetes: SH2B3 or ATXN2?
Not available
S-EPMC4058736 | biostudies-literature
TranscriptomicsTranscription profiling of early response of Arabidopsis root tips exposed to 1 hour of red light
Red light can affect a variety of responses in Arabidopsis. We characterize the early gene expression patterns of roots exposed to 1 hour of red light. Early genes indicate elements involved in photomorphogenesis, chloroplast development, PAL pathways, root hair development are regulated by 1 hour...
ORGANISM(S): Arabidopsis thaliana 
2007-10-04 | E-GEOD-4933 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of spleen samples from male and female BWF1 lupus-prone mice to investigate sex hormone regulated genes
Goal of experiment: Identification of differentially expressed immune genes from male and female BWF1 lupus-prone mice. (Female incidence is higher than male--attempting to find sex hormone regulated genes that may contribute to this difference).
ORGANISM(S): Mus musculus 
2007-12-04 | E-GEOD-2336 | biostudies-arrayexpress
ProteomicsResponse of C. jejuni to various environmental conditions
Campylobacter jejuni is the leading cause of foodborne human gastroenteritis in the developed world. Infections are largely acquired from poultry produced for human consumption and poor food handling is thus a major risk factor. In this study, C. jejuni were exposed to growth in a number of enviornm...
ORGANISM(S): Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 Bacteria 
2024-06-23 | PXD051724 | Pride
Deferroxamine Deoxycholate Chicken exudate Campylobacter 
TranscriptomicsTranscription profiling of Arabidopsis dark 7-day-old Arabidopsis whole seedlings vs. 1h red light
Red light can affect a variety of responses in Arabidopsis. We characterize the early gene expression patterns of seedlings exposed to 1 hour of red light using a small sized sample of 5, 7-day-old seedlings and also performed dark controls. Methods that were developed for tissue extraction and lab...
ORGANISM(S): Arabidopsis thaliana 
2009-04-18 | E-GEOD-13383 | biostudies-arrayexpress
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