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ProteomicsKaposi’s sarcoma-associated herpesvirus induces specialised ribosomes to efficiently translate viral lytic mRNAs
Historically, ribosomes have been viewed as unchanged homogeneous macromolecular machines with no intrinsic regulatory capacity for mRNA translation. However, an emerging concept is that heterogeneity of ribosomal composition exists, which can exert a regulatory function or specificity in translatio...
ORGANISM(S): Homo sapiens (Human) Human herpesvirus 8 strain rKSHV.219 
2022-12-21 | PXD032318 | Pride
Microbiology/virology/herpes virus/human/specalised ribosome/ribosome biogenesis 
ProteomicsThe Kaposi’s sarcoma-associated herpesvirus ORF11 protein interacts with pre-ribosome complexes during lytic replication
Historically, ribosomes have been viewed as unchanged homogeneous macromolecular machines with no intrinsic regulatory capacity for mRNA translation. However, an emerging concept is that heterogeneity of ribosomal composition exists, which can exert a regulatory function or specificity in translatio...
ORGANISM(S): Homo sapiens (Human) Human herpesvirus 8 strain rKSHV.219 
2022-12-21 | PXD032367 | Pride
Microbiology/kaposi’s sarcoma-associated herpesvirus/specalised ribosomes/ribosome biogenesis 
ProteomicsTREx-BCBL1-RTA GPRC5A-FLAG Immunoprecipitation LC-MS
The epitranscriptomic modification m6A is a ubiquitous feature of the mammalian transcriptome. It modulates mRNA fate and dynamics to exert regulatory control over numerous cellular processes and disease pathways, including viral infection. Kaposi’s sarcoma-associated herpesvirus (KSHV) reactivation...
ORGANISM(S): Homo sapiens (Human) Human gammaherpesvirus 8 
2023-07-20 | PXD039669 | Pride
Human kshv gprc5a 
ProteomicsSFPQ and KSHV protein ORF11 protein interactomes during lytic KSHV replication
The nucleus is a highly structured environment containing multiple membrane-less bodies formed through liquid-liquid phase separation. These provide spatial separation and concentration of specific biomolecules enabling efficient and discrete processes to occur which regulate gene expression. One su...
ORGANISM(S): Homo sapiens (Human) Human gammaherpesvirus 8 
2024-11-04 | PXD048834 | Pride
Kshv Sfpq Orf11 Paraspeckles Condensates 
GenomicsKaposi’s sarcoma-associated herpesvirus induces specialized ribosomes to efficiently translate viral lytic mRNAs
Kaposi’s sarcoma-associated herpesvirus induces specialized ribosomes to efficiently translate viral lytic mRNAs
PRJNA818335 | ENA
UnknownDysregulation of the miR-30c/DLL4 axis by circHIPK3 is essential for KSHV lytic replication
Not available
S-SCDT-EMBOR-2021-54117V1 | biostudies-other
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