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ProteomicsFANS unfixed: isolation and proteomic analysis of mouse cell type-specific brain nuclei
Epigenetic-mediated gene regulation orchestrates brain cell-type gene expression programmes, and epigenetic dysregulation is a major driver of aging and disease-associated changes. Proteins that mediate gene regulation are mostly localised to the nucleus, however, nuclear-localised proteins are ofte...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD053515 | Pride
Cell-type specific Proteomics Neurons Fans Microglia Epigenetics Oligodendrocytes 
ProteomicsMechanisms of increased Alzheimer’s Disease pathology with R47H and R62H TREM2 variants
TREM2 plays multiple functional roles in microglia and variants are associated with increased risks of Alzheimer’s disease (AD). CD33 polymorphisms are protective. Here we have contrasted cellular pathology in human post mortem brain with and without AD to test mechanisms associated with the differ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD074536 | Pride
Brain Neurodegeneration Trem2 Alzheimer's disease 
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